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Research ArticleHEALTH AND MEDICINE
Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing
- View ORCID ProfileNatascha Sommer1,
- View ORCID ProfileNasim Alebrahimdehkordi1,
- Oleg Pak1,
- Fenja Knoepp1,
- Ievgen Strielkov1,
- Susan Scheibe1,
- View ORCID ProfileEric Dufour2,
- View ORCID ProfileAna Andjelković2,
- View ORCID ProfileAkylbek Sydykov1,
- View ORCID ProfileAlireza Saraji1,
- Aleksandar Petrovic1,
- Karin Quanz1,
- Matthias Hecker1,
- Manish Kumar1,
- Joel Wahl3,
- Simone Kraut1,
- View ORCID ProfileWerner Seeger1,
- View ORCID ProfileRalph T. Schermuly1,
- View ORCID ProfileHossein A. Ghofrani1,4,
- View ORCID ProfileKerstin Ramser3,
- View ORCID ProfileThomas Braun5,
- Howard T. Jacobs2,
- View ORCID ProfileNorbert Weissmann1,* and
- View ORCID ProfileMarten Szibor2,*,†
- 1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
- 2Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.
- 3Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-97187 Luleå, Sweden.
- 4Department of Medicine, Imperial College London, Du Cane Road, Hammersmith Campus, London W12 0NN, UK.
- 5Department I, Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany.
- ↵*Corresponding author. Email: marten.szibor{at}tuni.fi (M.S.); norbert.weissmann{at}innere.med.uni-giessen.de (N.W.)
↵† Present address: Department of Cardiothoracic Surgery, Jena University Hospital, D-07747 Jena, Germany.
See allHide authors and affiliations
Science Advances 15 Apr 2020:
Vol. 6, no. 16, eaba0694
DOI: 10.1126/sciadv.aba0694
Vol. 6, no. 16, eaba0694
DOI: 10.1126/sciadv.aba0694
Natascha Sommer
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Nasim Alebrahimdehkordi
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Oleg Pak
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Fenja Knoepp
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Ievgen Strielkov
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Susan Scheibe
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Eric Dufour
2Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.
Ana Andjelković
2Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.
Akylbek Sydykov
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Alireza Saraji
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Aleksandar Petrovic
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Karin Quanz
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Matthias Hecker
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Manish Kumar
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Joel Wahl
3Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-97187 Luleå, Sweden.
Simone Kraut
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Werner Seeger
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Ralph T. Schermuly
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Hossein A. Ghofrani
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
4Department of Medicine, Imperial College London, Du Cane Road, Hammersmith Campus, London W12 0NN, UK.
Kerstin Ramser
3Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-97187 Luleå, Sweden.
Thomas Braun
5Department I, Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany.
Howard T. Jacobs
2Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.
Norbert Weissmann
1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
Marten Szibor
2Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.
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