Research ArticleCANCER
Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells
- View ORCID ProfileChen-Cheng Xue1,*,
- View ORCID ProfileMeng-Huan Li1,*,
- Yang Zhao2,*,
- Jun Zhou1,
- Yan Hu3,
- Kai-Yong Cai3,
- View ORCID ProfileYanli Zhao4,
- View ORCID ProfileShu-Hong Yu2,† and
- View ORCID ProfileZhong Luo1,†
- 1School of Life Science, Chongqing University, Chongqing 400044, P. R. China.
- 2Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Nanoscience, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, Hefei Science Center of CAS, University of Science and Technology of China, Hefei, 230026 China.
- 3Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing University, Chongqing 400044, P. R. China.
- 4Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371 Singapore.
- ↵†Corresponding author. Email: shyu{at}ustc.edu.cn (S.-H.Y.); luozhong918{at}cqu.edu.cn (Z.L.)
↵* These authors contributed equally to this work.
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Science Advances 29 Apr 2020:
Vol. 6, no. 18, eaax1346
DOI: 10.1126/sciadv.aax1346
Vol. 6, no. 18, eaax1346
DOI: 10.1126/sciadv.aax1346
Chen-Cheng Xue
1School of Life Science, Chongqing University, Chongqing 400044, P. R. China.
Meng-Huan Li
1School of Life Science, Chongqing University, Chongqing 400044, P. R. China.
Yang Zhao
2Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Nanoscience, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, Hefei Science Center of CAS, University of Science and Technology of China, Hefei, 230026 China.
Jun Zhou
1School of Life Science, Chongqing University, Chongqing 400044, P. R. China.
Yan Hu
3Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing University, Chongqing 400044, P. R. China.
Kai-Yong Cai
3Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing University, Chongqing 400044, P. R. China.
Yanli Zhao
4Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371 Singapore.
Shu-Hong Yu
2Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Nanoscience, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, Hefei Science Center of CAS, University of Science and Technology of China, Hefei, 230026 China.
Zhong Luo
1School of Life Science, Chongqing University, Chongqing 400044, P. R. China.
