Research ArticleIMMUNOLOGY

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

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Science Advances  29 Apr 2020:
Vol. 6, no. 18, eaax7881
DOI: 10.1126/sciadv.aax7881

Article Information

vol. 6 no. 18

Online ISSN: 
History: 
  • Received for publication April 23, 2019
  • Accepted for publication February 5, 2020
  • .

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Author Information

  1. Muhammad Zaeem Noman1,
  2. Santiago Parpal2,3,
  3. Kris Van Moer1,
  4. Malina Xiao1,
  5. Yasmin Yu2,3,
  6. Tsolere Arakelian1,
  7. Jenny Viklund2,
  8. Angelo De Milito2,3,
  9. Meriem Hasmim1,
  10. Martin Andersson2,
  11. Ravi K. Amaravadi4,
  12. Jessica Martinsson2,
  13. Guy Berchem1,5,* and
  14. Bassam Janji1,*,
  1. 1Tumor Immunotherapy and Microenvironment Group, Department of Oncology, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.
  2. 2Sprint Bioscience, Stockholm, Sweden.
  3. 3Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.
  4. 4Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  5. 5Department of Hemato-Oncology, Centre Hospitalier du Luxembourg, Luxembourg City, Luxembourg.
  1. Corresponding author. Email: bassam.janji{at}lih.lu
  • * Co-senior authors.

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