Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification

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Science Advances  29 Apr 2020:
Vol. 6, no. 18, eaay9526
DOI: 10.1126/sciadv.aay9526

Article Information

vol. 6 no. 18

Online ISSN: 
  • Received for publication July 31, 2019
  • Accepted for publication February 7, 2020
  • .

Author Information

  1. Yangwu Chen1,2,3,4,*,
  2. Weiliang Shen1,2,3,4,*,
  3. Chenqi Tang1,2,3,4,
  4. Jiayun Huang1,2,3,4,
  5. Chunmei Fan1,2,3,4,
  6. Zi Yin1,2,3,4,
  7. Yejun Hu1,2,3,4,
  8. Weishan Chen1,2,3,4,
  9. Hongwei Ouyang1,2,3,4,
  10. Yiting Zhou1,5,,
  11. Zhengwei Mao6, and
  12. Xiao Chen1,2,3,4,
  1. 1Dr. Li Dak Sum–Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  2. 2Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
  3. 3Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China.
  4. 4China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China
  5. 5Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, Zhejiang 310058, China.
  6. 6MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
  1. Corresponding author. Email: chenxiao-610{at} (X.C.); zwmao{at} (Z.M.); zhouyt{at} (Y.Z.)
  • * These authors contributed equally to this work.


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