Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells

Emmanuel Than-Trong; Bahareh Kiani; Nicolas Dray; Sara Ortica; Benjamin Simons; Steffen Rulands; Alessandro Alunni; Laure Bally-Cuif

doi:10.1126/sciadv.aaz5424

Research ArticleDEVELOPMENTAL BIOLOGY

Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells

View ORCID ProfileEmmanuel Than-Trong ¹,²,
Bahareh Kiani³,
View ORCID ProfileNicolas Dray¹,
Sara Ortica¹,
View ORCID ProfileBenjamin Simons ⁴,⁵,⁶,
View ORCID ProfileSteffen Rulands³,⁷,
View ORCID ProfileAlessandro Alunni¹,*,† and
View ORCID ProfileLaure Bally-Cuif ¹,*,†

¹Zebrafish Neurogenetics Unit, Institut Pasteur, UMR3738, CNRS, Team supported by the Ligue Nationale Contre le Cancer, Paris 75015, France.
²Université Paris-Saclay, Ecole Doctorale Biosigne, Le Kremlin-Bicêtre, France.
³Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany.
⁴Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.
⁵Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge UK.
⁶Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge UK.
⁷Center for Systems Biology Dresden, Pfotenhauer Str. 108, 01307 Dresden, Germany.

↵*Corresponding author. Email: laure.bally-cuif{at}pasteur.fr (L.B.-C.); alessandro.alunni{at}pasteur.fr (A.A.)

↵† These authors contributed equally to this work.

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Science Advances 29 Apr 2020:
Vol. 6, no. 18, eaaz5424
DOI: 10.1126/sciadv.aaz5424

Emmanuel Than-Trong

1Zebrafish Neurogenetics Unit, Institut Pasteur, UMR3738, CNRS, Team supported by the Ligue Nationale Contre le Cancer, Paris 75015, France.

2Université Paris-Saclay, Ecole Doctorale Biosigne, Le Kremlin-Bicêtre, France.

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ORCID record for Emmanuel Than-Trong

Bahareh Kiani

3Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany.

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Nicolas Dray

1Zebrafish Neurogenetics Unit, Institut Pasteur, UMR3738, CNRS, Team supported by the Ligue Nationale Contre le Cancer, Paris 75015, France.

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Sara Ortica

1Zebrafish Neurogenetics Unit, Institut Pasteur, UMR3738, CNRS, Team supported by the Ligue Nationale Contre le Cancer, Paris 75015, France.

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Benjamin Simons

4Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.

5Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge UK.

6Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge UK.

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Steffen Rulands

3Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany.

7Center for Systems Biology Dresden, Pfotenhauer Str. 108, 01307 Dresden, Germany.

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Alessandro Alunni

1Zebrafish Neurogenetics Unit, Institut Pasteur, UMR3738, CNRS, Team supported by the Ligue Nationale Contre le Cancer, Paris 75015, France.

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ORCID record for Alessandro Alunni
For correspondence: laure.bally-cuif@pasteur.fr alessandro.alunni@pasteur.fr

Laure Bally-Cuif

1Zebrafish Neurogenetics Unit, Institut Pasteur, UMR3738, CNRS, Team supported by the Ligue Nationale Contre le Cancer, Paris 75015, France.

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ORCID record for Laure Bally-Cuif
For correspondence: laure.bally-cuif@pasteur.fr alessandro.alunni@pasteur.fr

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Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells

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