Research ArticleIMMUNOLOGY
Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker–based immunotherapy
- View ORCID ProfileFeihu Wang1,2,*,
- View ORCID ProfileDongqing Xu3,*,
- View ORCID ProfileHao Su1,2,
- Weijie Zhang1,2,4,
- Xuanrong Sun1,5,
- View ORCID ProfileMaya K. Monroe1,2,
- View ORCID ProfileRami W. Chakroun1,2,
- View ORCID ProfileZongyuan Wang1,2,
- View ORCID ProfileWenbing Dai1,2,
- View ORCID ProfileRichard Oh1,
- View ORCID ProfileHan Wang1,2,
- View ORCID ProfileQin Fan1,2,
- View ORCID ProfileFengyi Wan3,6,7,† and
- View ORCID ProfileHonggang Cui1,2,7,†
- 1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
- 2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
- 3Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
- 4Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
- 5Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
- 6Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
- 7Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- ↵†Corresponding author. Email: fwan1{at}jhu.edu (F.W.); hcui6{at}jhu.edu (H.C.)
↵* These authors contributed equally to this work.
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Science Advances 29 Apr 2020:
Vol. 6, no. 18, eaaz8985
DOI: 10.1126/sciadv.aaz8985
Vol. 6, no. 18, eaaz8985
DOI: 10.1126/sciadv.aaz8985
Feihu Wang
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
Dongqing Xu
3Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Hao Su
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
Weijie Zhang
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
4Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Xuanrong Sun
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
5Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Maya K. Monroe
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
Rami W. Chakroun
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
Zongyuan Wang
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
Wenbing Dai
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
Richard Oh
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Han Wang
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
Qin Fan
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
Fengyi Wan
3Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
6Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
7Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Honggang Cui
1Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
2Institute for NanoBiotechnology (INBT), Johns Hopkins University, Baltimore, MD 21218, USA.
7Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
