Congenital Zika syndrome is associated with maternal protein malnutrition

J. Barbeito-Andrés; P. Pezzuto; L. M. Higa; A. A. Dias; J. M. Vasconcelos; T. M. P. Santos; J. C. C. G. Ferreira; R. O. Ferreira; F. F. Dutra; A. D. Rossi; R. V. Barbosa; C. K. N. Amorim; M. P. C. De Souza; L. Chimelli; R. S. Aguiar; P. N. Gonzalez; F. A. Lara; M. C. Castro; Z. Molnár; R. T. Lopes; M. T. Bozza; J. L. S. G. Vianez; C. G. Barbeito; P. Cuervo; M. Bellio; A. Tanuri; P. P. Garcez

doi:10.1126/sciadv.aaw6284

Research ArticleVIROLOGY

Congenital Zika syndrome is associated with maternal protein malnutrition

View ORCID ProfileJ. Barbeito-Andrés¹,²,
View ORCID ProfileP. Pezzuto³,
View ORCID ProfileL. M. Higa³,
View ORCID ProfileA. A. Dias⁴,
View ORCID ProfileJ. M. Vasconcelos⁵,
T. M. P. Santos⁶,
View ORCID ProfileJ. C. C. G. Ferreira¹,
View ORCID ProfileR. O. Ferreira¹,
F. F. Dutra⁴,
A. D. Rossi³,
View ORCID ProfileR. V. Barbosa⁷,
C. K. N. Amorim⁸,
View ORCID ProfileM. P. C. De Souza⁸,
View ORCID ProfileL. Chimelli⁹,
View ORCID ProfileR. S. Aguiar³,
View ORCID ProfileP. N. Gonzalez²,
View ORCID ProfileF. A. Lara¹⁰,
View ORCID ProfileM. C. Castro¹¹,
View ORCID ProfileZ. Molnár¹²,
View ORCID ProfileR. T. Lopes⁶,
View ORCID ProfileM. T. Bozza⁴,
View ORCID ProfileJ. L. S. G. Vianez⁸,
C. G. Barbeito¹³,
View ORCID ProfileP. Cuervo¹⁰,
View ORCID ProfileM. Bellio⁴,
View ORCID ProfileA. Tanuri³ and
View ORCID ProfileP. P. Garcez¹,*

¹Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
²Institute for Studies in Neuroscience and Complex Systems (ENyS) CONICET, Buenos Aires, Argentina.
³Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
⁴Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
⁵Biological Science Institute, Federal University of Pará, Belém, Brazil.
⁶Nuclear Instrumentation Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
⁷CENABIO (National Center of Structural Biology and Bioimaging), Rio de Janeiro, Brazil.
⁸Technological Innovations Centre, Evandro Chagas Institute, Ananindeua, Brazil.
⁹State Institute of Brain Paulo Niemeyer, Rio de Janeiro, Brazil.
¹⁰Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
¹¹Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
¹²Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
¹³Faculty of Veterinary Sciences, National University of La Plata, Buenos Aires, Argentina.

↵*Corresponding author. Email: ppgarcez{at}icb.ufrj.br

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Science Advances 10 Jan 2020:
Vol. 6, no. 2, eaaw6284
DOI: 10.1126/sciadv.aaw6284

J. Barbeito-Andrés

1Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

2Institute for Studies in Neuroscience and Complex Systems (ENyS) CONICET, Buenos Aires, Argentina.

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P. Pezzuto

3Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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L. M. Higa

3Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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A. A. Dias

4Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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J. M. Vasconcelos

5Biological Science Institute, Federal University of Pará, Belém, Brazil.

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T. M. P. Santos

6Nuclear Instrumentation Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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J. C. C. G. Ferreira

1Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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R. O. Ferreira

1Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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F. F. Dutra

4Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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A. D. Rossi

3Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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R. V. Barbosa

7CENABIO (National Center of Structural Biology and Bioimaging), Rio de Janeiro, Brazil.

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C. K. N. Amorim

8Technological Innovations Centre, Evandro Chagas Institute, Ananindeua, Brazil.

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M. P. C. De Souza

8Technological Innovations Centre, Evandro Chagas Institute, Ananindeua, Brazil.

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L. Chimelli

9State Institute of Brain Paulo Niemeyer, Rio de Janeiro, Brazil.

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R. S. Aguiar

3Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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P. N. Gonzalez

2Institute for Studies in Neuroscience and Complex Systems (ENyS) CONICET, Buenos Aires, Argentina.

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F. A. Lara

10Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.

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M. C. Castro

11Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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Z. Molnár

12Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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R. T. Lopes

6Nuclear Instrumentation Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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M. T. Bozza

4Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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J. L. S. G. Vianez

8Technological Innovations Centre, Evandro Chagas Institute, Ananindeua, Brazil.

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C. G. Barbeito

13Faculty of Veterinary Sciences, National University of La Plata, Buenos Aires, Argentina.

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P. Cuervo

10Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.

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M. Bellio

4Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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A. Tanuri

3Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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P. P. Garcez

1Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

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For correspondence: ppgarcez@icb.ufrj.br

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