Research ArticleDEVELOPMENTAL BIOLOGY

PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly

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Science Advances  10 Jan 2020:
Vol. 6, no. 2, eaax9852
DOI: 10.1126/sciadv.aax9852

Article Information

vol. 6 no. 2

Online ISSN: 
History: 
  • Received for publication May 10, 2019
  • Accepted for publication September 30, 2019
  • .

Author Information

  1. Slim Mzoughi1,2,
  2. Federico Di Tullio1,
  3. Diana H. P. Low1,
  4. Corina-Mihaela Motofeanu1,
  5. Sheena L. M. Ong3,
  6. Heike Wollmann1,
  7. Cheng Mun Wun1,
  8. Paul Kruszka4,
  9. Maximilian Muenke4,
  10. Friedhelm Hildebrandt5,
  11. N. Ray Dunn3,
  12. Daniel M. Messerschmidt1 and
  13. Ernesto Guccione1,2,6,7,*
  1. 1Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.
  2. 2Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  3. 3Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore.
  4. 4Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  5. 5Department of Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  7. 7Department of Pharmacological Sciences and Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  1. *Corresponding author. Email: ernesto.guccione{at}mssm.edu

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