Research ArticleCELL BIOLOGY

Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization

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Science Advances  15 May 2020:
Vol. 6, no. 20, eaay1057
DOI: 10.1126/sciadv.aay1057

Article Information

vol. 6 no. 20

Online ISSN: 
History: 
  • Received for publication May 20, 2019
  • Accepted for publication March 5, 2020
  • .

Author Information

  1. Jaspreet Banga1,*,
  2. Dinesh Srinivasan2,*,,
  3. Chia-Chi Sun3,
  4. Cherrie D. Thompson1,
  5. Francesca Milletti4,,
  6. Kuo-Sen Huang2,
  7. Shannon Hamilton2,
  8. Su Song1,
  9. Ann F. Hoffman2,§,
  10. Yajuan Gu Qin2,
  11. Bharati Matta1,
  12. Margaret LaPan1,
  13. Qin Guo1,
  14. Gang Lu2,
  15. Dan Li1,
  16. Hong Qian2,||,
  17. David R. Bolin2,
  18. Lena Liang2,
  19. Charles Wartchow2,
  20. Jin Qiu3,
  21. Michelle Downing3,
  22. Satwant Narula2,
  23. Nader Fotouhi2,
  24. Julie A. DeMartino2,3,
  25. Seng-Lai Tan2,
  26. Gang Chen2,3, and
  27. Betsy J. Barnes1,5,,#
  1. 1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
  2. 2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  3. 3EMD Serono Research and Development Institute Inc., 45A Middlesex Turnpike, Billerica, MA 01821, USA.
  4. 4Roche Innovation Center New York, 430 East 29th Street, New York, NY 10016, USA.
  5. 5Departments of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.
  1. Corresponding author. Email: bbarnes1{at}northwell.edu (B.J.B.); gang.chen{at}emdserono.com (G.C.)
  • * These authors contributed equally to this work.

  • Present address: AzurRx BioPharma Inc., 760 Parkside Avenue, Downstate Biotechnology Incubator, Suite 304, Brooklyn, NY 11226, USA.

  • Present address: Kite Pharma, 1800 Stewart Street, Santa Monica, CA 90404, USA.

  • § Present address: Platform of Technology and Science, GlaxoSmithKline, 1250 S Collegeville Rd., Collegeville, PA 19426, USA.

  • || Present address: Novartis Pharmaceuticals, 1 Health Plaza, East Hanover, NJ 07936, USA.

  • # Lead contact.

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