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Research ArticleCELL BIOLOGY
Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization
- View ORCID ProfileJaspreet Banga1,*,
- View ORCID ProfileDinesh Srinivasan2,*,†,
- Chia-Chi Sun3,
- Cherrie D. Thompson1,
- Francesca Milletti4,‡,
- View ORCID ProfileKuo-Sen Huang2,
- View ORCID ProfileShannon Hamilton2,
- Su Song1,
- Ann F. Hoffman2,§,
- Yajuan Gu Qin2,
- View ORCID ProfileBharati Matta1,
- View ORCID ProfileMargaret LaPan1,
- Qin Guo1,
- Gang Lu2,
- Dan Li1,
- Hong Qian2,||,
- David R. Bolin2,
- Lena Liang2,
- View ORCID ProfileCharles Wartchow2,
- Jin Qiu3,
- View ORCID ProfileMichelle Downing3,
- Satwant Narula2,
- Nader Fotouhi2,
- View ORCID ProfileJulie A. DeMartino2,3,
- Seng-Lai Tan2,
- View ORCID ProfileGang Chen2,3,¶ and
- View ORCID ProfileBetsy J. Barnes1,5,¶,#
- 1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
- 2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
- 3EMD Serono Research and Development Institute Inc., 45A Middlesex Turnpike, Billerica, MA 01821, USA.
- 4Roche Innovation Center New York, 430 East 29th Street, New York, NY 10016, USA.
- 5Departments of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.
- ↵¶Corresponding author. Email: bbarnes1{at}northwell.edu (B.J.B.); gang.chen{at}emdserono.com (G.C.)
↵* These authors contributed equally to this work.
↵† Present address: AzurRx BioPharma Inc., 760 Parkside Avenue, Downstate Biotechnology Incubator, Suite 304, Brooklyn, NY 11226, USA.
↵‡ Present address: Kite Pharma, 1800 Stewart Street, Santa Monica, CA 90404, USA.
↵§ Present address: Platform of Technology and Science, GlaxoSmithKline, 1250 S Collegeville Rd., Collegeville, PA 19426, USA.
↵|| Present address: Novartis Pharmaceuticals, 1 Health Plaza, East Hanover, NJ 07936, USA.
↵# Lead contact.
See allHide authors and affiliations
Science Advances 15 May 2020:
Vol. 6, no. 20, eaay1057
DOI: 10.1126/sciadv.aay1057
Vol. 6, no. 20, eaay1057
DOI: 10.1126/sciadv.aay1057
Jaspreet Banga
1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
Dinesh Srinivasan
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Chia-Chi Sun
3EMD Serono Research and Development Institute Inc., 45A Middlesex Turnpike, Billerica, MA 01821, USA.
Cherrie D. Thompson
1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
Francesca Milletti
4Roche Innovation Center New York, 430 East 29th Street, New York, NY 10016, USA.
Kuo-Sen Huang
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Shannon Hamilton
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Su Song
1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
Ann F. Hoffman
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Yajuan Gu Qin
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Bharati Matta
1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
Margaret LaPan
1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
Qin Guo
1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
Gang Lu
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Dan Li
1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
Hong Qian
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
David R. Bolin
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Lena Liang
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Charles Wartchow
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Jin Qiu
3EMD Serono Research and Development Institute Inc., 45A Middlesex Turnpike, Billerica, MA 01821, USA.
Michelle Downing
3EMD Serono Research and Development Institute Inc., 45A Middlesex Turnpike, Billerica, MA 01821, USA.
Satwant Narula
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Nader Fotouhi
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Julie A. DeMartino
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
3EMD Serono Research and Development Institute Inc., 45A Middlesex Turnpike, Billerica, MA 01821, USA.
Seng-Lai Tan
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Gang Chen
2Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
3EMD Serono Research and Development Institute Inc., 45A Middlesex Turnpike, Billerica, MA 01821, USA.
Betsy J. Barnes
1The Feinstein Institute for Medical Research, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, 350 Community Dr., Manhasset, NY 11030, USA.
5Departments of Molecular Medicine and Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.
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