Research ArticleDEVELOPMENTAL BIOLOGY

Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos

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Science Advances  13 May 2020:
Vol. 6, no. 20, eaaz0298
DOI: 10.1126/sciadv.aaz0298

Article Information

vol. 6 no. 20

Online ISSN: 
History: 
  • Received for publication August 6, 2019
  • Accepted for publication March 2, 2020
  • .

Author Information

  1. Zhixing Hu1,*,
  2. Hanqin Li1,*,
  3. Houbo Jiang1,
  4. Yong Ren1,
  5. Xinyang Yu2,
  6. Jingxin Qiu3,
  7. Aimee B. Stablewski4,
  8. Boyang Zhang1,
  9. Michael J. Buck2 and
  10. Jian Feng1,
  1. 1Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.
  2. 2Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14203, USA.
  3. 3Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
  4. 4Gene Targeting and Transgenic Shared Resource, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
  1. Corresponding author. Email: jianfeng{at}buffalo.edu
  • * These authors contributed equally to this work.

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