Research ArticleHEALTH AND MEDICINE

Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice

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Science Advances  13 May 2020:
Vol. 6, no. 20, eaaz5195
DOI: 10.1126/sciadv.aaz5195

Article Information

vol. 6 no. 20

Online ISSN: 
History: 
  • Received for publication September 16, 2019
  • Accepted for publication February 28, 2020
  • .

Author Information

  1. Takefumi Yamaguchi1,2,*,
  2. Kazunari Higa1,2,
  3. Yukari Yagi-Yaguchi1,2,
  4. Koji Ueda3,
  5. Hisashi Noma4,
  6. Shinsuke Shibata5,
  7. Toshihiro Nagai5,
  8. Daisuke Tomida1,
  9. Ririko Yasu-Mimura1,2,
  10. Osama Ibrahim1,2,
  11. Ryo Matoba6,
  12. Kazuo Tsubota1,2,
  13. Pedram Hamrah7,8,
  14. Jun Yamada9,
  15. Kohsuke Kanekura10,* and
  16. Jun Shimazaki1,2
  1. 1Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa-shi, Chiba 272-8513, Japan.
  2. 2Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
  3. 3Project for Realization of Personalized Cancer Medicine, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo 135-8550, Japan.
  4. 4Department of Data Science, The Institute of Statistical Mathematics, 10-3, Midori-cho, Tachikawa, Tokyo 190-0014, Japan.
  5. 5Electron Microscope Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.
  6. 6DNA Chip Research Inc., Suzue Baydium 5F, 1-15-1, Kaigan, Minato-ku, Tokyo 105-0022, Japan.
  7. 7Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, 800 Washington St., Boston, MA 02111, USA.
  8. 8Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, 800 Washington St., Boston, MA 02111, USA.
  9. 9Department of Ophthalmology, Meiji University of Integrative Medicine, Hinotani 6-1, Honoda, Hiyoshi-cho, Nantan-shi, Kyoto 629-0392, Japan.
  10. 10Department of Molecular Pathology, Tokyo Medical University, 6-1-1, Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
  1. *Corresponding author. Email: tym.i.eye.i{at}gmail.com (T.Y.); Kanekura{at}tokyo-med.ac.jp (K.K.)

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