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Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates

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Science Advances  13 May 2020:
Vol. 6, no. 20, eaaz9165
DOI: 10.1126/sciadv.aaz9165

Article Information

vol. 6 no. 20

Online ISSN: 
History: 
  • Received for publication October 21, 2019
  • Accepted for publication March 6, 2020
  • .

Author Information

  1. M. Bourdenx1,2,*,,
  2. A. Nioche1,2,3,4,*,,
  3. S. Dovero1,2,*,
  4. M.-L. Arotcarena1,2,*,
  5. S. Camus1,2,
  6. G. Porras1,2,
  7. M.-L. Thiolat1,2,
  8. N. P. Rougier1,2,5,
  9. A. Prigent6,7,8,
  10. P. Aubert6,7,8,
  11. S. Bohic9,
  12. C. Sandt10,
  13. F. Laferrière1,2,
  14. E. Doudnikoff1,2,
  15. N. Kruse11,12,
  16. B. Mollenhauer11,12,
  17. S. Novello13,14,
  18. M. Morari13,14,
  19. T. Leste-Lasserre15,
  20. I. Trigo-Damas16,17,
  21. M. Goillandeau1,2,
  22. C. Perier17,18,
  23. C. Estrada19,20,
  24. N. Garcia-Carrillo21,
  25. A. Recasens17,18,
  26. N. N. Vaikath22,
  27. O. M. A. El-Agnaf22,
  28. M. T. Herrero19,20,
  29. P. Derkinderen6,7,8,
  30. M. Vila17,18,23,24,
  31. J. A. Obeso16,17,
  32. B. Dehay1,2,§,|| and
  33. E. Bezard1,2,§,||
  1. 1Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
  2. 2CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
  3. 3Institut Jean Nicod, Département d’études cognitives, ENS, EHESS, PSL Research University, 75005 Paris, France.
  4. 4Institut Jean Nicod, Département d’études cognitives, CNRS, UMR 8129, Paris, France.
  5. 5INRIA Bordeaux Sud-Ouest, 33405 Talence, France.
  6. 6INSERM, U1235, Nantes F-44035, France.
  7. 7Nantes University, Nantes F-44035, France.
  8. 8CHU Nantes, Department of Neurology, Nantes F-44093, France.
  9. 9EA-7442 Rayonnement Synchrotron et Recherche Medicale, RSRM, University of Grenoble Alpes, 38000 Grenoble, France.
  10. 10SMIS beamline, Synchrotron SOLEIL, l’orme des merisiers, 91192 Gif sur Yvette, France.
  11. 11Paracelsus-Elena-Klinik, Kassel, Germany.
  12. 12University Medical Center Goettingen, Institute of Neuropathology, Goettingen, Germany.
  13. 13Department of Medical Sciences, Section of Pharmacology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy.
  14. 14Neuroscience Center and National Institute of Neuroscience, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy.
  15. 15INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France.
  16. 16HM CINAC, HM Puerta del Sur and CEU–San Pablo University Madrid, E-28938 Mostoles, Spain.
  17. 17Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain.
  18. 18Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)–Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
  19. 19Clinical and Experimental Neuroscience Unit, School of Medicine, Biomedical Research Institute of Murcia (IMIB), University of Murcia, Campus Mare Nostrum, 30100 Murcia, Spain.
  20. 20Institute of Research on Aging (IUIE), School of Medicine, University of Murcia, 30100 Murcia, Spain.
  21. 21Centro Experimental en Investigaciones Biomédica (CEIB), Universidad de Murcia, Murcia, Spain.
  22. 22Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Education City, Qatar.
  23. 23Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona (UAB), Barcelona, Spain.
  24. 24Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
  1. §Corresponding author. Email: benjamin.dehay{at}u-bordeaux.fr (B.D.); erwan.bezard{at}u-bordeaux.fr (E.B.)
  • * These authors contributed equally to this work.

  • Present address: Albert Einstein College of Medicine, Department of Developmental and Molecular Biology, 1300 Morris Park Ave., Bronx, NY 10461, USA.

  • Present address: Aalto University, School of Electrical Engineering, Department of Communications and Networking, 02150 Espoo, Finland.

  • || These authors contributed equally to this work as co-last authors.

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