Research ArticleNEUROSCIENCE
Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
- View ORCID ProfileJianpan Huang1,
- Peter C. M. van Zijl2,3,
- View ORCID ProfileXiongqi Han1,
- Celia M. Dong4,
- View ORCID ProfileGerald W. Y. Cheng5,
- View ORCID ProfileKai-Hei Tse5,
- View ORCID ProfileLinda Knutsson2,6,
- View ORCID ProfileLin Chen2,3,
- View ORCID ProfileJoseph H. C. Lai1,
- View ORCID ProfileEd X. Wu4,
- View ORCID ProfileJiadi Xu2,3,* and
- View ORCID ProfileKannie W. Y. Chan1,2,7,*
- 1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
- 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
- 4Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
- 5Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
- 6Department of Medical Radiation Physics, Lund University, Lund, Sweden.
- 7City University of Hong Kong Shenzhen Research Institute, Shenzhen, China.
- ↵*Corresponding author. Email: kanniew.y.c{at}cityu.edu.hk (K.W.Y.C.); xuj{at}kennedykrieger.org (J.X.)
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Science Advances 13 May 2020:
Vol. 6, no. 20, eaba3884
DOI: 10.1126/sciadv.aba3884
Vol. 6, no. 20, eaba3884
DOI: 10.1126/sciadv.aba3884
Jianpan Huang
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
Peter C. M. van Zijl
2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Xiongqi Han
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
Celia M. Dong
4Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
Gerald W. Y. Cheng
5Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Kai-Hei Tse
5Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Linda Knutsson
2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
6Department of Medical Radiation Physics, Lund University, Lund, Sweden.
Lin Chen
2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Joseph H. C. Lai
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
Ed X. Wu
4Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
Jiadi Xu
2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA.
Kannie W. Y. Chan
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
7City University of Hong Kong Shenzhen Research Institute, Shenzhen, China.
