Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

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Science Advances  22 May 2020:
Vol. 6, no. 21, eaax3333
DOI: 10.1126/sciadv.aax3333

Article Information

vol. 6 no. 21

Online ISSN: 
  • Received for publication March 14, 2019
  • Accepted for publication March 11, 2020
  • .

Author Information

  1. J. Guerra1,
  2. A.-L. Valadao1,
  3. D. Vlachakis2,
  4. K. Polak1,
  5. I. K. Vila1,
  6. C. Taffoni1,
  7. T. Prabakaran3,
  8. A. S. Marriott4,
  9. R. Kaczmarek5,
  10. A. Houel6,
  11. B. Auzemery1,
  12. S. Déjardin1,
  13. P. Boudinot6,
  14. B. Nawrot5,
  15. N. J. Jones7,
  16. S. R. Paludan3,
  17. S. Kossida8,
  18. C. Langevin6,* and
  19. N. Laguette1,
  1. 1Institut de Génétique Humaine, CNRS, Université de Montpellier, Molecular Basis of Inflammation Laboratory, Montpellier, France.
  2. 2Laboratory of Genetics, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, Athens, Greece.
  3. 3Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
  4. 4Department of Biology, Edge Hill University, Ormskirk, L39 4QP, UK.
  5. 5Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Poland.
  6. 6Université Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
  7. 7Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.
  8. 8Institut de Génétique Humaine, CNRS, Université de Montpellier, IMGT, the International ImMunoGeneTics Information System, Montpellier, France.
  1. Corresponding author. Email: nadine.laguette{at}
  • * Present address: Université Paris-Saclay, INRAE, IERP, 78350 Jouy-en-Josas, France.


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