Research ArticleHEALTH AND MEDICINE

Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell–based cartilage tissue engineering

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Science Advances  22 May 2020:
Vol. 6, no. 21, eaaz5913
DOI: 10.1126/sciadv.aaz5913

Article Information

vol. 6 no. 21

PubMed: 
Online ISSN: 
History: 
  • Received for publication September 22, 2019
  • Accepted for publication March 17, 2020
  • .

Author Information

  1. Junmin Lee1,2,3,*,
  2. Oju Jeon4,5,*,
  3. Ming Kong6,7,8,
  4. Amr A. Abdeen9,
  5. Jung-Youn Shin4,
  6. Ha Neul Lee10,
  7. Yu Bin Lee4,5,
  8. Wujin Sun1,2,3,
  9. Praveen Bandaru1,2,3,
  10. Daniel S. Alt4,5,
  11. KangJu Lee1,2,3,
  12. Han-Jun Kim1,2,3,
  13. Sang Jin Lee4,5,
  14. Somali Chaterji11,12,
  15. Su Ryon Shin7,8,
  16. Eben Alsberg4,5,13,14,15,16,17,18, and
  17. Ali Khademhosseini1,2,3,7,8,19,20,21,
  1. 1Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  2. 2Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA 90095, USA.
  3. 3California NanoSystems Institute (CNSI), University of California, Los Angeles, Los Angeles, CA 90095, USA.
  4. 4Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
  5. 5Department of Bioengineering, University of Illinois-Chicago, Chicago, IL 60607, USA.
  6. 6College of Marine Life Science, Ocean University of China, Yushan Road, Qingdao, Shandong Province 266003, China.
  7. 7Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
  8. 8Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  9. 9Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA.
  10. 10Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  11. 11Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.
  12. 12Center for Resilient Infrastructures, Systems, and Processes (CRISP), Purdue University, West Lafayette, IN 47907, USA.
  13. 13Department of Orthopaedics, University of Illinois-Chicago, Chicago, IL 60612, USA.
  14. 14Department of Orthopaedic Surgery, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
  15. 15National Center for Regenerative Medicine, Division of General Medical Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
  16. 16School of Dentistry, Kyung Hee University, Seoul 130-701, South Korea.
  17. 17Department of Pharmacology, University of Illinois-Chicago, Chicago, IL 60612, USA.
  18. 18Department of Mechanical and Industrial Engineering, University of Illinois-Chicago, Chicago, IL 60607, USA.
  19. 19Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  20. 20Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  21. 21Terasaki Institute for Biomedical Innovation Los Angeles, CA 90064, USA.
  1. Corresponding author. Email: ealsberg{at}uic.edu (E.A.); khademh{at}terasaki.org (A.K.)
  • * These authors contributed equally to this work.

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