Research ArticleCANCER
Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy
- View ORCID ProfileStephanie J. Wang1,2,
- View ORCID ProfileRan Li2,
- View ORCID ProfileThomas S. C. Ng2,
- View ORCID ProfileGaurav Luthria2,3,
- View ORCID ProfileMadeleine J. Oudin4,
- Mark Prytyskach2,
- View ORCID ProfileRainer H. Kohler2,
- View ORCID ProfileRalph Weissleder2,5,6,
- View ORCID ProfileDouglas A. Lauffenburger1,* and
- View ORCID ProfileMiles A. Miller2,5,*
- 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
- 2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
- 3Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
- 4Department of Biomedical Engineering, Tufts University, Medford, MA, USA.
- 5Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
- 6Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
- ↵*Corresponding author. Email: lauffen{at}mit.edu (D.A.L.); miles.miller{at}mgh.harvard.edu (M.A.M.)
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Science Advances 22 May 2020:
Vol. 6, no. 21, eaaz8521
DOI: 10.1126/sciadv.aaz8521
Vol. 6, no. 21, eaaz8521
DOI: 10.1126/sciadv.aaz8521
Stephanie J. Wang
1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Ran Li
2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Thomas S. C. Ng
2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Gaurav Luthria
2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
3Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Madeleine J. Oudin
4Department of Biomedical Engineering, Tufts University, Medford, MA, USA.
Mark Prytyskach
2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Rainer H. Kohler
2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
Ralph Weissleder
2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
5Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
6Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
Douglas A. Lauffenburger
1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Miles A. Miller
2Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
5Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
