Research ArticleCELL BIOLOGY

Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8+ T cell response in tumor

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Science Advances  29 May 2020:
Vol. 6, no. 22, eaba5412
DOI: 10.1126/sciadv.aba5412

Article Information

vol. 6 no. 22

PubMed: 
Online ISSN: 
History: 
  • Received for publication December 13, 2019
  • Accepted for publication March 25, 2020
  • .

Author Information

  1. Yuan Wang1,*,
  2. Xinting Wang1,*,
  3. Xiaoteng Cui1,*,
  4. Yue Zhuo2,
  5. Hongshuai Li1,
  6. Chuanbo Ha1,
  7. Lingbiao Xin1,
  8. Yuanyuan Ren1,
  9. Wei Zhang1,
  10. Xiaoming Sun1,
  11. Lin Ge1,
  12. Xin Liu1,
  13. Jinyan He1,
  14. Tao Zhang2,
  15. Kai Zhang1,
  16. Zhi Yao1,,
  17. Xi Yang3, and
  18. Jie Yang1,
  1. 1Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Key Laboratory of Cellular and Molecular Immunology, Excellent Talent Project, Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
  2. 2School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
  3. 3Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
  1. Corresponding author. Email: yangj{at}tmu.edu.cn (J.Y.); yaozhi{at}tmu.edu.cn (Z.Y.); x.yang{at}umanitoba.ca (X.Y.)
  • * These authors contributed equally to this work.

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