Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8+ T cell response in tumor

Yuan Wang; Xinting Wang; Xiaoteng Cui; Yue Zhuo; Hongshuai Li; Chuanbo Ha; Lingbiao Xin; Yuanyuan Ren; Wei Zhang; Xiaoming Sun; Lin Ge; Xin Liu; Jinyan He; Tao Zhang; Kai Zhang; Zhi Yao; Xi Yang; Jie Yang

doi:10.1126/sciadv.aba5412

Research ArticleCELL BIOLOGY

Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8⁺ T cell response in tumor

View ORCID ProfileYuan Wang ¹,*,
View ORCID ProfileXinting Wang ¹,*,
View ORCID ProfileXiaoteng Cui¹,*,
Yue Zhuo²,
Hongshuai Li¹,
View ORCID ProfileChuanbo Ha¹,
View ORCID ProfileLingbiao Xin¹,
Yuanyuan Ren¹,
Wei Zhang¹,
Xiaoming Sun¹,
Lin Ge¹,
Xin Liu¹,
Jinyan He¹,
Tao Zhang²,
View ORCID ProfileKai Zhang¹,
View ORCID ProfileZhi Yao ¹,†,
View ORCID ProfileXi Yang³,† and
View ORCID ProfileJie Yang ¹,†

¹Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Key Laboratory of Cellular and Molecular Immunology, Excellent Talent Project, Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
²School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
³Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.

↵†Corresponding author. Email: yangj{at}tmu.edu.cn (J.Y.); yaozhi{at}tmu.edu.cn (Z.Y.); x.yang{at}umanitoba.ca (X.Y.)

↵* These authors contributed equally to this work.

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Science Advances 29 May 2020:
Vol. 6, no. 22, eaba5412
DOI: 10.1126/sciadv.aba5412

Yuan Wang

1Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Key Laboratory of Cellular and Molecular Immunology, Excellent Talent Project, Department of Biochemistry and Molecular Biology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

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Xinting Wang

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Xiaoteng Cui

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Yue Zhuo

2School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.

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Hongshuai Li

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Chuanbo Ha

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Lingbiao Xin

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Yuanyuan Ren

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Wei Zhang

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Xiaoming Sun

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Lin Ge

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Xin Liu

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Jinyan He

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Tao Zhang

2School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.

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Kai Zhang

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Zhi Yao

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For correspondence: yangj@tmu.edu.cn yaozhi@tmu.edu.cn x.yang@umanitoba.ca

Xi Yang

3Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.

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For correspondence: yangj@tmu.edu.cn yaozhi@tmu.edu.cn x.yang@umanitoba.ca

Jie Yang

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For correspondence: yangj@tmu.edu.cn yaozhi@tmu.edu.cn x.yang@umanitoba.ca

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Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8⁺ T cell response in tumor

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