Research ArticleGENETICS

Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway

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Science Advances  03 Jun 2020:
Vol. 6, no. 23, eabb2236
DOI: 10.1126/sciadv.abb2236

Article Information

vol. 6 no. 23

Online ISSN: 
History: 
  • Received for publication February 8, 2020
  • Accepted for publication March 31, 2020
  • .

Author Information

  1. Harry Kemble1,2,*,
  2. Catherine Eisenhauer1,
  3. Alejandro Couce1,3,
  4. Audrey Chapron1,
  5. Mélanie Magnan1,
  6. Gregory Gautier4,5,
  7. Hervé Le Nagard1,
  8. Philippe Nghe2,* and
  9. Olivier Tenaillon1,*
  1. 1IAME, INSERM, Université de Paris, Université Paris Nord, 75018 Paris, France.
  2. 2Laboratory of Biochemistry (LBC), Chimie Biologie et Innovation, ESPCI Paris, PSL University, CNRS, 75005 Paris, France.
  3. 3Department of Life Sciences, Imperial College, London SW7 2AZ, UK.
  4. 4Centre de Recherche sur l'Inflammation, INSERM, UMRS 1149, 75018 Paris, France.
  5. 5Laboratoire d’Excellence INFLAMEX, Université de Paris, Sorbonne Paris Cité, 75018 Paris, France.
  1. *Corresponding author. Email: kembleharry{at}gmail.com (H.K.); philippe.nghe{at}espci.fr (P.N.); olivier.tenaillon{at}inserm.fr (O.T.)

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