Research ArticleHEALTH AND MEDICINE
Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma
- View ORCID ProfileAdriana L. da Silva1,2,
- View ORCID ProfileGisele P. de Oliveira1,
- View ORCID ProfileNamho Kim3,4,
- View ORCID ProfileFernanda F. Cruz1,
- View ORCID ProfileJamil Z. Kitoko5,
- View ORCID ProfileNatalia G. Blanco1,
- View ORCID ProfileSabrina V. Martini2,
- View ORCID ProfileJustin Hanes3,4,6,
- View ORCID ProfilePatricia R. M. Rocco1,
- View ORCID ProfileJung Soo Suk3,4,6,* and
- View ORCID ProfileMarcelo M. Morales2,*
- 1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
- 2Laboratory of Cellular and Molecular Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
- 3Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- 4Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
- 5Laboratory of Inflammation and Immunity, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
- 6Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- ↵*Corresponding author. Email: jsuk{at}jhmi.edu (J.S.S.); mmorales{at}biof.ufrj.br (M.M.M.)
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Science Advances 10 Jun 2020:
Vol. 6, no. 24, eaay7973
DOI: 10.1126/sciadv.aay7973
Vol. 6, no. 24, eaay7973
DOI: 10.1126/sciadv.aay7973
Adriana L. da Silva
1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
2Laboratory of Cellular and Molecular Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Gisele P. de Oliveira
1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Namho Kim
3Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
4Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Fernanda F. Cruz
1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Jamil Z. Kitoko
5Laboratory of Inflammation and Immunity, Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Natalia G. Blanco
1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Sabrina V. Martini
2Laboratory of Cellular and Molecular Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Justin Hanes
3Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
4Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
6Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Patricia R. M. Rocco
1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Jung Soo Suk
3Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
4Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
6Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marcelo M. Morales
2Laboratory of Cellular and Molecular Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
