Research ArticleIMMUNOLOGY
Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery
- View ORCID ProfileYanpu He1,2,
- View ORCID ProfileCelestine Hong1,2,
- View ORCID ProfileEmily Z. Yan1,2,
- Samantha J. Fletcher1,2,
- Ge Zhu3,
- View ORCID ProfileMengdi Yang3,
- Yingzhong Li1,4,
- Xin Sun3,
- View ORCID ProfileDarrell J. Irvine1,4,5,6,
- View ORCID ProfileJiahe Li3,* and
- View ORCID ProfilePaula T. Hammond1,2,*
- 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 3Department of Biological Engineering, Northeastern University, Boston, MA 02115, USA.
- 4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 6Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
- ↵*Corresponding author. Email: jiah.li{at}northeastern.edu (J.L.); hammond{at}mit.edu (P.T.H.)
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Science Advances 12 Jun 2020:
Vol. 6, no. 24, eaba7589
DOI: 10.1126/sciadv.aba7589
Vol. 6, no. 24, eaba7589
DOI: 10.1126/sciadv.aba7589
Yanpu He
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Celestine Hong
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Emily Z. Yan
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Samantha J. Fletcher
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ge Zhu
3Department of Biological Engineering, Northeastern University, Boston, MA 02115, USA.
Mengdi Yang
3Department of Biological Engineering, Northeastern University, Boston, MA 02115, USA.
Yingzhong Li
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Xin Sun
3Department of Biological Engineering, Northeastern University, Boston, MA 02115, USA.
Darrell J. Irvine
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
6Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Jiahe Li
3Department of Biological Engineering, Northeastern University, Boston, MA 02115, USA.
Paula T. Hammond
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
