Contents
June 2020
Vol 6, Issue 25
Vol 6, Issue 25
Contents
Research Articles
- Cytosolic delivery of proteins by cholesterol tagging
This platform can deliver proteins for intracellular imaging and therapeutic targets while bypassing endocytosis sequestration.
- Strain rate–dependent mechanical metamaterials
Metamaterials with strain rate–dependent buckling behavior, switchable auxeticity, and negative viscoelasticity are demonstrated.
- Keeping pace with climate change in global terrestrial protected areas
Climatic representation in protected areas—and not just the amount—is critical to safeguarding biodiversity under climate change.
- Spontaneous and field-induced crystallographic reorientation of metal electrodeposits at battery anodes
Metals use a chemotaxis-like process to overcome diffusion limitations and prevent dendritic electrodeposition in batteries.
- Allosteric pluripotency as revealed by protein kinase A
Subcellular environments control how signaling sensors respond to allosteric effectors by remodeling the free-energy landscape.
- Programming van der Waals interactions with complex symmetries into microparticles using liquid crystallinity
Using liquid crystals to program van der Waals interactions for bottom-up assembly.
- Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
Details of intestinal sterol absorption and inhibition by cholesterol-lowering drug are uncovered in new protein structures.
- Rationally designed indium oxide catalysts for CO2 hydrogenation to methanol with high activity and selectivity
A novel hexagonal In2O3 with high proportion of exposed {104} facets shows superior performance for CO2 hydrogenation to CH3OH.
- Early-career faculty practice learner-centered teaching up to 9 years after postdoctoral professional development
Professional development leads to persistence in teaching approaches and practices over time and across a career transition.
- LiQD Cornea: Pro-regeneration collagen mimetics as patches and alternatives to corneal transplantation
LiQD Cornea is a liquid in situ gelling, pro-regeneration hydrogel for treating corneal blindness and repairing perforations.
- Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition
This study presents strategies to render triple-negative breast cancers sensitive to CDK4/6 inhibitors.
- Programmable and scalable transfer printing with high reliability and efficiency for flexible inorganic electronics
The shape-conformal stamp with active surface microstructures was used for programmable and scalable transfer printing.
- Chemokine receptor CXCR3 is required for lethal brain pathology but not pathogen clearance during cryptococcal meningoencephalitis
CXCR3 axis promotes lethal CNS pathology but is a dispensable fungal control in cryptococcal meningoencephalitis.
- Probing the low-temperature limit of the quantum anomalous Hall effect
The low occurring temperature of quantum anomalous Hall effect is a result of weak ferromagnetism and trivial band involvement.
- Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease
Phase transition microneedles provide an optimal administration method for cardiac gene therapy.
- High-loading single Pt atom sites [Pt-O(OH)x] catalyze the CO PROX reaction with high activity and selectivity at mild conditions
Pt atoms stabilized by alkaline ions efficiently and selectively catalyze CO oxidation under H2 rich conditions (PROX).
- The value of what’s to come: Neural mechanisms coupling prediction error and the utility of anticipation
Hippocampal-midbrain circuit boosts the utility of anticipation in the prefrontal cortex and drives information-seeking behavior.
- Engineering autologous tumor cell vaccine to locally mobilize antitumor immunity in tumor surgical bed
A feasible and transformable cancer vaccine was designed for personalized immunotherapy of postoperative tumors.
- The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency
The strength of humoral and cellular immune responses is regulated by the properties of mesoporous silica.
- Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA
CjeCas9 causes DNA damage in human cells.
- Synaptic mechanisms for motor variability in a feedforward network
Two Aplysia command neurons drive motor programs with various levels of variability through synaptic noise and different strength.
- Probing dynamical phase transitions with a superconducting quantum simulator
Superconducting simulators are used to investigate dynamical phase transitions, revealing their applications in quantum metrology.
- Nuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues
Decreasing physical impediments to migration through nuclear softening can improve dense connective tissue repair.
- Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression
DAP3 represses adenosine-to-inosine (A-to-I) RNA editing in cancer cells and promotes cancer progression.
- Mate discrimination among subspecies through a conserved olfactory pathway
Differential interpretation of a sex pheromone promotes formation of new species in Drosophila.
- Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope
Tibetan antelope have adapted to high-altitude hypoxia via juvenilization of blood properties.
- High-capacity poly(2-oxazoline) formulation of TLR 7/8 agonist extends survival in a chemo-insensitive, metastatic model of lung adenocarcinoma
Polymeric micelle formulation of an immune modulator improves survival in a highly aggressive model of non–small cell lung cancer.
- 3D printed deformable sensors
A 3D printer can print a soft sensor on a deformable surface such as a breathing lung for spatiotemporal mapping of deformation.
- Smithian growth in a nonindustrial society
The archaeological record provides model systems for investigating fundamental processes of economic growth.
- Human TRA2A determines influenza A virus host adaptation by regulating viral mRNA splicing
The human host factor TRA2A plays an important role in cross-species transmission of avian influenza virus.
- Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
Host deaminases shape the viral RNA genome and its evolution by targeting its RNA.
- TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis
TET2 deficiency reprograms B cell epigenome linked to lymphomagenesis.
- Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells
The kinetic properties of transcriptional bursting were comprehensively analyzed in mouse embryonic stem cells.
- A reversible oxygen redox reaction in bulk-type all-solid-state batteries
A high-capacity positive electrode active material Li2RuO3-Li2SO4 for all-solid-state batteries was developed.
- Charge-reversal surfactant antibiotic material for reducing microbial corrosion in petroleum exploitation and transportation
The sulfate-reducing bacteria and related corrosion can be inhibited by charge-reversal surfactant antibiotic material.
- Operando detection of single nanoparticle activity dynamics inside a model pore catalyst material
Nanofluidic model pores are used to visualize single catalyst particle activity dynamics induced by local reactant conversion.
- Snoek-type damping performance in strong and ductile high-entropy alloys
We developed high-temperature high-damping high-entropy alloys with superior mechanical properties via Snoek relaxation.
- Million-year lag times in a post-orogenic sediment conveyor
Reworking of old sediment in the Murray-Darling implies alteration of environmental signals traveling from source to sink.
- An orthogonally regulatable DNA nanodevice for spatiotemporally controlled biorecognition and tumor treatment
Orthogonal near-infrared light–controlled DNA nanodevices allow for biorecognition and treatment at right time and place.
- Motion tracking of 80-nm-size skyrmions upon directional current injections
Drift, Hall, and torque motions of single 80-nm skyrmions and clusters tracked with directional current at low current density.
About The Cover
ONLINE COVER Most bovids (members of the cattle family) express a fetal hemoglobin isoform with higher oxygen affinity than the adult isoform, which maintains a difference in oxygen affinity that facilitates oxygen transfer across the placenta from mother to fetus. However, most bovids wouldn't be able to match the feats of the Tibetan antelope, which can sustain running speeds of more than 70 kilometers per hour over distances of greater than 100 kilometers, at altitudes where the partial pressure of oxygen is roughly half that at sea level. To investigate whether and how the Tibetan antelope evolved to express this early hemoglobin isoform into adulthood, Signore and Storz characterized the genomic organization of globin genes in Tibetan antelope and other bovids using published genome assemblies. Next, the researchers estimated how different forms of the β-globin gene influenced bovid evolutionary history, finding that the Tibetan antelope inherited the same three-part β-globin genes as goats and sheep, with the middle gene block containing βA (which corresponds to juvenile hemoglobin) later deleted. Through in vitro experiments, Signore and Storz confirmed that Tibetan antelope hemoglobin does, in fact, have a much higher oxygen affinity than that of all other bovids. [CREDIT: XI ZHINONG/MINDEN]
