Research ArticleHEALTH AND MEDICINE

Nuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues

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Science Advances  19 Jun 2020:
Vol. 6, no. 25, eaax5083
DOI: 10.1126/sciadv.aax5083

Article Information

vol. 6 no. 25

Online ISSN: 
History: 
  • Received for publication April 5, 2019
  • Accepted for publication April 28, 2020
  • .

Author Information

  1. Su-Jin Heo1,2,3,
  2. Kwang Hoon Song3,4,*,
  3. Shreyasi Thakur5,*,
  4. Liane M. Miller1,2,*,
  5. Xuan Cao3,6,
  6. Ana P. Peredo1,2,
  7. Breanna N. Seiber1,2,
  8. Feini Qu1,2,
  9. Tristan P. Driscoll1,2,
  10. Vivek B. Shenoy3,4,6,
  11. Melike Lakadamyali3,5,
  12. Jason A. Burdick2,3,4 and
  13. Robert L. Mauck1,2,3,4,
  1. 1McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  2. 2Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
  3. 3Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA USA.
  4. 4Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.
  5. 5Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  6. 6Department of Materials Science Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.
  1. Corresponding author. Email: lemauck{at}pennmedicine.upenn.edu
  • * These authors contributed equally to this work.

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