Research ArticleCANCER

TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis

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Science Advances  17 Jun 2020:
Vol. 6, no. 25, eaay5872
DOI: 10.1126/sciadv.aay5872

Article Information

vol. 6 no. 25

PubMed: 
Online ISSN: 
History: 
  • Received for publication July 1, 2019
  • Accepted for publication March 25, 2020
  • .

Author Information

  1. Wojciech Rosikiewicz1,2,*,,
  2. Xiaowen Chen1,*,
  3. Pilar M. Dominguez3,*,,
  4. Hussein Ghamlouch4,
  5. Said Aoufouchi5,
  6. Olivier A. Bernard4,
  7. Ari Melnick3,§ and
  8. Sheng Li1,6,7,8,§
  1. 1The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  2. 2Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA.
  3. 3Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY, USA.
  4. 4INSERM U1170, équipe labelisée Ligue Nationale Contre le Cancer, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  5. 5CNRS UMR8200, équipe labelisée Ligue Nationale Contre le Cancer, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  6. 6The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA.
  7. 7Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA.
  8. 8Department of Computer Science and Engineering, University of Connecticut, Storrs, CT, USA.
  1. §Corresponding author. Email: amm2014{at}med.cornell.edu (A.M.); sheng.li{at}jax.org (S.L.)
  • * These authors contributed equally to this work.

  • Present address: Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA.

  • Present address: Cancer Research Division, Peter MacCallum Cancer Centre, and The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia.

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