TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis

Wojciech Rosikiewicz; Xiaowen Chen; Pilar M. Dominguez; Hussein Ghamlouch; Said Aoufouchi; Olivier A. Bernard; Ari Melnick; Sheng Li

doi:10.1126/sciadv.aay5872

Research ArticleCANCER

TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis

View ORCID ProfileWojciech Rosikiewicz¹,²,*,†,
View ORCID ProfileXiaowen Chen¹,*,
View ORCID ProfilePilar M. Dominguez ³,*,‡,
View ORCID ProfileHussein Ghamlouch⁴,
View ORCID ProfileSaid Aoufouchi⁵,
Olivier A. Bernard⁴,
View ORCID ProfileAri Melnick ³,§ and
View ORCID ProfileSheng Li ¹,⁶,⁷,⁸,§

¹The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
²Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA.
³Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY, USA.
⁴INSERM U1170, équipe labelisée Ligue Nationale Contre le Cancer, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
⁵CNRS UMR8200, équipe labelisée Ligue Nationale Contre le Cancer, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
⁶The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA.
⁷Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA.
⁸Department of Computer Science and Engineering, University of Connecticut, Storrs, CT, USA.

↵§Corresponding author. Email: amm2014{at}med.cornell.edu (A.M.); sheng.li{at}jax.org (S.L.)

↵* These authors contributed equally to this work.
↵† Present address: Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA.
↵‡ Present address: Cancer Research Division, Peter MacCallum Cancer Centre, and The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia.

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Science Advances 17 Jun 2020:
Vol. 6, no. 25, eaay5872
DOI: 10.1126/sciadv.aay5872

Wojciech Rosikiewicz

1The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

2Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, USA.

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Xiaowen Chen

1The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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Pilar M. Dominguez

3Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY, USA.

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Hussein Ghamlouch

4INSERM U1170, équipe labelisée Ligue Nationale Contre le Cancer, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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Said Aoufouchi

5CNRS UMR8200, équipe labelisée Ligue Nationale Contre le Cancer, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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Olivier A. Bernard

4INSERM U1170, équipe labelisée Ligue Nationale Contre le Cancer, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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Ari Melnick

3Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY, USA.

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For correspondence: amm2014@med.cornell.edu sheng.li@jax.org

Sheng Li

1The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

6The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA.

7Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA.

8Department of Computer Science and Engineering, University of Connecticut, Storrs, CT, USA.

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For correspondence: amm2014@med.cornell.edu sheng.li@jax.org

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TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis

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