Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease

Hongpeng Shi; Tong Xue; Yang Yang; Chenyu Jiang; Shixing Huang; Qi Yang; Dong Lei; Zhengwei You; Tuo Jin; Fei Wu; Qiang Zhao; Xiaofeng Ye

doi:10.1126/sciadv.aaz3621

Research ArticleHEALTH AND MEDICINE

Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease

View ORCID ProfileHongpeng Shi¹,*,
View ORCID ProfileTong Xue²,*,
Yang Yang³,
View ORCID ProfileChenyu Jiang¹,
View ORCID ProfileShixing Huang¹,
Qi Yang¹,
Dong Lei⁴,
Zhengwei You⁴,
Tuo Jin²,
View ORCID ProfileFei Wu ²,†,
View ORCID ProfileQiang Zhao ¹,† and
View ORCID ProfileXiaofeng Ye ¹,†

¹Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China.
²School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
³Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P. R. China.
⁴State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-Dimension Materials, College of Materials Science and Engineering Donghua University, Shanghai 201620, P. R. China.

↵†Corresponding author. Email: xiaofengye{at}hotmail.com (X.Y.); zq11607{at}rjh.com.cn (Q.Z.); feiwu{at}sjtu.edu.cn (F.W.)

↵* These authors contributed equally to this work.

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Science Advances 17 Jun 2020:
Vol. 6, no. 25, eaaz3621
DOI: 10.1126/sciadv.aaz3621

Hongpeng Shi

1Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China.

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Tong Xue

2School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

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Yang Yang

3Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P. R. China.

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Chenyu Jiang

1Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China.

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ORCID record for Chenyu Jiang

Shixing Huang

1Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China.

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Qi Yang

1Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China.

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Dong Lei

4State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-Dimension Materials, College of Materials Science and Engineering Donghua University, Shanghai 201620, P. R. China.

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Zhengwei You

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Tuo Jin

2School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

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Fei Wu

2School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

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For correspondence: xiaofengye@hotmail.com zq11607@rjh.com.cn feiwu@sjtu.edu.cn

Qiang Zhao

1Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China.

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For correspondence: xiaofengye@hotmail.com zq11607@rjh.com.cn feiwu@sjtu.edu.cn

Xiaofeng Ye

1Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China.

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ORCID record for Xiaofeng Ye
For correspondence: xiaofengye@hotmail.com zq11607@rjh.com.cn feiwu@sjtu.edu.cn

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Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease

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