Research ArticleGENETICS

Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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Science Advances  17 Jun 2020:
Vol. 6, no. 25, eaaz6699
DOI: 10.1126/sciadv.aaz6699

Article Information

vol. 6 no. 25

PubMed: 
Online ISSN: 
History: 
  • Received for publication October 3, 2019
  • Accepted for publication March 25, 2020
  • .

Author Information

  1. Hiroshi Ochiai1,2,*,
  2. Tetsutaro Hayashi3,
  3. Mana Umeda3,
  4. Mika Yoshimura3,
  5. Akihito Harada4,
  6. Yukiko Shimizu5,
  7. Kenta Nakano5,
  8. Noriko Saitoh6,
  9. Zhe Liu7,
  10. Takashi Yamamoto1,2,
  11. Tadashi Okamura5,8,
  12. Yasuyuki Ohkawa4,
  13. Hiroshi Kimura9 and
  14. Itoshi Nikaido3,10,*
  1. 1Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-0046, Japan.
  2. 2Genome Editing Innovation Center, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-0046, Japan.
  3. 3Laboratory for Bioinformatics Research, RIKEN BDR, Wako, Saitama 351-0198, Japan.
  4. 4Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812-0054, Japan.
  5. 5Department of Animal Medicine, National Center for Global Health and Medicine (NCGM), Tokyo 812-0054, Japan.
  6. 6Division of Cancer Biology, The Cancer Institute of JFCR, Tokyo 135-8550, Japan.
  7. 7Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
  8. 8Section of Animal Models, Department of Infectious Diseases, National Center for Global Health and Medicine (NCGM), Tokyo 812-0054, Japan.
  9. 9Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8503, Japan.
  10. 10Bioinformatics Course, Master’s/Doctoral Program in Life Science Innovation (T-LSI), School of Integrative and Global Majors (SIGMA), University of Tsukuba, Wako 351-0198, Japan.
  1. *Corresponding author. Email: ochiai{at}hiroshima-u.ac.jp (H.O.); itoshi.nikaido{at}riken.jp (I.N.)

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