Research ArticleHEALTH AND MEDICINE

High-capacity poly(2-oxazoline) formulation of TLR 7/8 agonist extends survival in a chemo-insensitive, metastatic model of lung adenocarcinoma

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Science Advances  17 Jun 2020:
Vol. 6, no. 25, eaba5542
DOI: 10.1126/sciadv.aba5542

Article Information

vol. 6 no. 25

PubMed: 
Online ISSN: 
History: 
  • Received for publication December 12, 2019
  • Accepted for publication May 6, 2020
  • .

Author Information

  1. Natasha Vinod1,2,
  2. Duhyeong Hwang1,
  3. Salma H. Azam3,
  4. Amanda E. D. Van Swearingen3,*,
  5. Elizabeth Wayne1,
  6. Sloane Christian Fussell4,
  7. Marina Sokolsky-Papkov1,
  8. Chad V. Pecot3,5,6, and
  9. Alexander V. Kabanov1,7,
  1. 1Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA.
  2. 2Joint UNC/NC State Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599-7575, USA.
  3. 3Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  4. 4Department of Biology, Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  5. 5Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  6. 6Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  7. 7Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119992, Russia.
  1. Corresponding author. Email: pecot{at}email.unc.edu (C.V.P.); kabanov{at}email.unc.edu (A.V.K.)
  • * Present address: Duke Center for Brain and Spine Metastasis, Duke Cancer Institute, Durham, NC 27710, USA.

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