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Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition

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Science Advances  17 Jun 2020:
Vol. 6, no. 25, eabb2210
DOI: 10.1126/sciadv.abb2210

Article Information

vol. 6 no. 25

PubMed: 
Online ISSN: 
History: 
  • Received for publication February 8, 2020
  • Accepted for publication May 4, 2020
  • .

Author Information

  1. Anne Fassl1,2,
  2. Christopher Brain3,
  3. Monther Abu-Remaileh4,5,6,
  4. Iga Stukan1,
  5. Deborah Butter1,
  6. Piotr Stepien1,
  7. Avery S. Feit7,8,
  8. Johann Bergholz1,9,
  9. Wojciech Michowski1,2,
  10. Tobias Otto1,2,
  11. Qing Sheng3,
  12. Alice Loo3,
  13. Walter Michael3,
  14. Ralph Tiedt10,
  15. Carmine DeAngelis11,12,13,
  16. Rachel Schiff11,12,
  17. Baishan Jiang1,9,
  18. Bojana Jovanovic7,8,
  19. Karolina Nowak1,
  20. Maria Ericsson14,
  21. Michael Cameron15,
  22. Nathanael Gray1,9,
  23. Deborah Dillon16,
  24. Jean J. Zhao1,9,17,
  25. David M. Sabatini4,17,18,19,
  26. Rinath Jeselsohn7,8,
  27. Myles Brown7,8,
  28. Kornelia Polyak7,8,* and
  29. Piotr Sicinski1,2,*
  1. 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  2. 2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA.
  4. 4Whitehead Institutes for Biomedical Research and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  5. 5Departments of Chemical Engineering and Genetics, Stanford University, Stanford, CA 94305, USA.
  6. 6Institute for Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, 290 Jane Stanford Way, Stanford, CA 94305, USA.
  7. 7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  8. 8Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  9. 9Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  10. 10Novartis Institutes for Biomedical Research, Oncology Disease Area, 4057 Basel, Switzerland.
  11. 11Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
  12. 12Department of Medicine and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
  13. 13Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  14. 14Electron Microscopy Facility, Harvard Medical School, Boston, MA 02115, USA.
  15. 15Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA.
  16. 16Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
  17. 17Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  18. 18Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  19. 19Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  1. *Corresponding author. Email: kornelia_polyak{at}dfci.harvard.edu (K.P.); peter_sicinski{at}dfci.harvard.edu (P.S.)

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