Research ArticleIMMUNOLOGY

Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells

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Science Advances  03 Jul 2020:
Vol. 6, no. 27, eaaz7809
DOI: 10.1126/sciadv.aaz7809

Article Information

vol. 6 no. 27

Online ISSN: 
  • Received for publication October 8, 2019
  • Accepted for publication May 26, 2020
  • .

Author Information

  1. Jan A. Rath1,*,
  2. Gagan Bajwa2,*,
  3. Benoit Carreres1,
  4. Elisabeth Hoyer2,
  5. Isabelle Gruber1,
  6. Melisa A. Martínez-Paniagua3,
  7. Yi-Ru Yu1,
  8. Nazila Nouraee2,
  9. Fatemeh Sadeghi3,
  10. Mengfen Wu4,
  11. Tao Wang4,
  12. Michael Hebeisen1,
  13. Nathalie Rufer1,
  14. Navin Varadarajan3,
  15. Ping-Chih Ho1,
  16. Malcolm K. Brenner2,5,6,7,
  17. David Gfeller1 and
  18. Caroline Arber1,2,5,
  1. 1Department of Oncology UNIL-CHUV, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.
  2. 2Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children’s Hospital, Houston, TX, USA.
  3. 3Department of Chemical and Biomolecular Engineering, University of Houston, TX, USA.
  4. 4Biostatistics Shared Resource, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
  5. 5Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
  6. 6Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  7. 7Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
  1. Corresponding author. Email: caroline.arber{at}
  • * These authors contributed equally to this work and are co-first authors.


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