Contents
July 2020
Vol 6, Issue 28
Vol 6, Issue 28
Contents
Research Articles
- Paired EMI-HIMU hotspots in the South Atlantic—Starting plume heads trigger compositionally distinct secondary plumes?
Initiation of Tristan-Gough and Shona EMI plumes triggers secondary HIMU plumes, generating overlapping EMI-HIMU hotspot tracks.
- Seismic anisotropy reveals crustal flow driven by mantle vertical loading in the Pacific NW
Seismic anisotropy reveals that gravitational loads in the upper mantle drive crustal deformation in the Pacific NW.
- Transient structures in rupturing thin films: Marangoni-induced symmetry-breaking pattern formation in viscous fluids
A transient pattern formation on the top of a soap bubble induced by surface tension gradients is examined via asymptotics.
- Habituation is not neutral or equal: Individual differences in tolerance suggest an overlooked personality trait
Wild habituated baboons show individual differences in tolerance to researcher proximity that may undermine behavioral data.
- Spin stress contribution to the lattice dynamics of FePt
Two-pulse laser excitation of FePt nanolayers distinguishes ultrafast stresses of magnetic excitations from the Poisson effect.
- One-dimensional organic artificial multi-synapses enabling electronic textile neural network for wearable neuromorphic applications
We developed 1D multi-synaptic device toward the development of an e-textile neutral network for wearable intelligent applications.
- Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors
A far-red light–activated split-Cas9 (FAST) system was developed for controlling gene editing in both mammalian cells and mice.
- Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung.
- Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
Human lung single-cell atlas reveals the complexity and diversity of aberrant cellular populations in pulmonary fibrosis.
- Chirality-induced bacterial rheotaxis in bulk shear flows
Experimental orientation distributions reveal scaling laws of bacterial rheotaxis explained using noisy dynamical systems.
- ChIA-PIPE: A fully automated pipeline for comprehensive ChIA-PET data analysis and visualization
New genome pipeline enables seamless execution of processing, analyzing, and visualizing of ChIA-PET data.
- Characteristic boundaries associated with three-dimensional twins in hexagonal metals
The 3D facets controlling the growth of the most common twin in magnesium have been identified.
- Elusive consensus: Polarization in elite communication on the COVID-19 pandemic
In discussing the COVID-19 pandemic during the early stages of the crisis, members of Congress polarized along party lines.
- Smart, soft contact lens for wireless immunosensing of cortisol
This study presents a smart, soft contact lens that provides real-time sensing for the wireless immunosensing of cortisol.
- Abrupt decline in tropospheric nitrogen dioxide over China after the outbreak of COVID-19
Chinese COVID-19 policies indirectly lead to reduced fuel use and reduction in environmental emissions.
- The bystander effect in rats
In rats as in humans, nonhelping bystanders suppress helping whereas naive bystanders boost helping above individual levels.
- Self-powered user-interactive electronic skin for programmable touch operation platform
We report a self-powered user-interactive electronic skin with seamless integration of visual and electrical mapping of pressure.
- Tip-induced flipping of droplets on Janus pillars: From local reconfiguration to global transport
Tip-induced flipping achieves fast and efficient transport of fog droplets without the need of external energy.
- Chemical identification through two-dimensional electron energy-loss spectroscopy
A disruptive approach to molecular sensing is presented based on ballistic electron energy loss analysis in 2D semiconductors.
- One-step vapor-phase synthesis of transparent high refractive index sulfur-containing polymers
Colorless, transparent polymer thin films with n > 1.9 were prepared through vapor deposition polymerization of elemental sulfur.
- IRONSperm: Sperm-templated soft magnetic microrobots
IRONSperms are microrobots templated by sperm cells, powered by magnetic fields, loaded with drugs, and localized by ultrasound.
- Evolutionarily conserved sequence motif analysis guides development of chemically defined hydrogels for therapeutic vascularization
Motif analysis on evolutionarily conserved regions in laminin enabled the discovery of novel ligands for hydrogel development.
- Full-color active-matrix organic light-emitting diode display on human skin based on a large-area MoS2 backplane
The consistent and controlled functioning of a large-area full-color OLED display with a MoS2 backplane was demonstrated.
- MRNIP is a replication fork protection factor
MRNIP interacts directly with the MRE11:RAD50 nuclease to protect nascent DNA from degradation and consequent genome instability.
- Detection of response to tumor microenvironment–targeted cellular immunotherapy using nano-radiomics
Data mining of nanoparticle contrast–enhanced 3D images reveals phenotypes indicative of tumor response to cellular immunotherapy.
- Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations
We investigate particle injectability as an essential parameter for design of microparticle-based drug delivery systems.
- Prolate and oblate chiral liquid crystal spheroids
Mechanical strain, curvature, and elasticity lead to the emergence of exotic molecular configurations in chiral liquid crystals.
- Phylogenetic and physiological signals in metazoan fossil biomolecules
Fossilization yields stable polymers diagnostic of tissue type, biomineralization, and the place of animals in the tree of life.
- Molecular and functional architecture of the mouse photoreceptor network
Genetic dissection and paired recordings reveal the prevalence of connexin36-mediated rod/cone coupling in the mouse retina.
- A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
Integrated microneedle patch serves as substitutes for multiple daily insulin injections.
- Dynamic metal-polymer interaction for the design of chemoselective and long-lived hydrogenation catalysts
Dynamic interaction between Pd and polyphenylene sulfide enables the design of selective and long-lived hydrogenation catalyst.
- Ester dance reaction on the aromatic ring
Ester groups on an aromatic ring can be translocated from one carbon atom to another, leading to an unprecedented “ester dance.”
- TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy
TIP60 K430 SUMOylation inactivates DNA-PKcs to facilitate DNA HR repair, and emerging target for radiation and PARPi cancer therapy.
- Structure-based drug designing and immunoinformatics approach for SARS-CoV-2
We report development of in-silico approaches for the identification of anti-coronaviral drugs against SARS-CoV-2.
- Attenuation of Dupuytren’s fibrosis via targeting of the STAT1 modulated IL-13Rα1 response
Targeting STAT pathways may offer previously unidentified approaches in the management of fibrotic disorders.
- Dynamic 3D meta-holography in visible range with large frame number and high frame rate
A space channel design approach achieves dynamic meta-holography with high frame rate and large frame number.
- Extensive morphological variability in asexually produced planktic foraminifera
Planktic foraminifera reproduce sexually and asexually, overturning assumptions of heritability and dispersal.
- A long-lived magma ocean on a young Moon
Fitting the isotopic composition of lunar rocks to a new thermal and crystallization model shows the Moon formed 4.40 to 4.45 Ga.
- Cooperation between passive and active silicon transporters clarifies the ecophysiology and evolution of biosilicification in sponges
Molecular mechanisms for Si transport constrain the evolution and ecological adaptability of sponges.
- Ecosystem stability and Native American oyster harvesting along the Atlantic Coast of the United States
Five thousand–year history of Native American oyster harvesting practices provides insight into modern oyster reef restoration.
Erratum
Editorials
About The Cover
ONLINE COVER More than one million people worldwide suffer from pulmonary fibrosis, a deadly disease in which damage in the lungs creates scar tissue that interferes with the lungs' function. While both environmental (e.g. cigarette smoking) and genetic factors contribute to the development of pulmonary fibrosis, the molecular mechanisms underlying the disease have proven difficult to understand. Due to the diverse cellular makeup of the lungs, single-cell technologies such as single-cell RNA sequencing (scRNA-seq) provide a promising platform for scientists to unravel the lungs' cellular complexity and pinpoint key molecular and cellular changes. Habermann et al. performed scRNA-seq of single-cell suspensions from 20 lungs with pulmonary fibrosis and 10 control lungs without the disease, providing a high-resolution view of the changes that occur in lung cells with pulmonary fibrosis, including a shift in epithelial cell phenotypes. In another study, Adams et al. profiled 312,928 nuclei from 32 lungs with idiopathic pulmonary fibrosis (IPF), 28 smoker and non-smoker control lungs, and 18 lungs with chronic obstructive pulmonary disease (COPD). Both studies identified novel cell types/states including a population of abnormal profibrotic epithelial cells in lungs from patients with pulmonary fibrosis that simultaneously express epithelial, mesenchymal, aging, and developmental markers. [CREDIT: KROPSKI LAN, VANDERBILT UNIVERSITY MEDICAL CENTER]
