Research ArticleDISEASES AND DISORDERS
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
- View ORCID ProfileArun C. Habermann1,*,
- Austin J. Gutierrez2,*,
- View ORCID ProfileLinh T. Bui2,*,
- View ORCID ProfileStephanie L. Yahn2,
- Nichelle I. Winters1,
- Carla L. Calvi1,
- Lance Peter2,
- Mei-I Chung2,
- View ORCID ProfileChase J. Taylor1,
- View ORCID ProfileChristopher Jetter3,
- View ORCID ProfileLatha Raju4,
- Jamie Roberson4,
- Guixiao Ding1,
- Lori Wood5,
- Jennifer M. S. Sucre3,
- Bradley W. Richmond1,6,
- Ana P. Serezani1,
- View ORCID ProfileWyatt J. McDonnell7,†,
- Simon B. Mallal7,8,9,
- Matthew J. Bacchetta10,
- James E. Loyd1,
- View ORCID ProfileCiara M. Shaver1,
- Lorraine B. Ware1,7,
- View ORCID ProfileRoss Bremner5,
- View ORCID ProfileRajat Walia5,
- Timothy S. Blackwell1,6,11,
- View ORCID ProfileNicholas E. Banovich2,‡,§ and
- View ORCID ProfileJonathan A. Kropski1,6,11,‡,§
- 1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
- 2Translational Genomics Research Institute, Phoenix, AZ, USA.
- 3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 4Vanderbilt Center for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 5Department of Thoracic Disease and Transplantation, Norton Thoracic Institute, Phoenix, AZ, USA.
- 6Department of Veterans Affairs Medical Center, Nashville, TN, USA.
- 7Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 8Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
- 9Institute for Immunology and Infectious Diseases, Murdoch University, Discovery Way, Murdoch, Western Australia 6150, Australia.
- 10Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
- 11Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
- ↵§Corresponding author. Email: jon.kropski{at}vumc.org (J.A.K.); nbanovich{at}tgen.org (N.E.B.)
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Science Advances 08 Jul 2020:
Vol. 6, no. 28, eaba1972
DOI: 10.1126/sciadv.aba1972
Vol. 6, no. 28, eaba1972
DOI: 10.1126/sciadv.aba1972
Arun C. Habermann
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Austin J. Gutierrez
2Translational Genomics Research Institute, Phoenix, AZ, USA.
Linh T. Bui
2Translational Genomics Research Institute, Phoenix, AZ, USA.
Stephanie L. Yahn
2Translational Genomics Research Institute, Phoenix, AZ, USA.
Nichelle I. Winters
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Carla L. Calvi
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lance Peter
2Translational Genomics Research Institute, Phoenix, AZ, USA.
Mei-I Chung
2Translational Genomics Research Institute, Phoenix, AZ, USA.
Chase J. Taylor
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Christopher Jetter
3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Latha Raju
4Vanderbilt Center for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN, USA.
Jamie Roberson
4Vanderbilt Center for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN, USA.
Guixiao Ding
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lori Wood
5Department of Thoracic Disease and Transplantation, Norton Thoracic Institute, Phoenix, AZ, USA.
Jennifer M. S. Sucre
3Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Bradley W. Richmond
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
6Department of Veterans Affairs Medical Center, Nashville, TN, USA.
Ana P. Serezani
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wyatt J. McDonnell
7Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Simon B. Mallal
7Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
8Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
9Institute for Immunology and Infectious Diseases, Murdoch University, Discovery Way, Murdoch, Western Australia 6150, Australia.
Matthew J. Bacchetta
10Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
James E. Loyd
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ciara M. Shaver
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lorraine B. Ware
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
7Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ross Bremner
5Department of Thoracic Disease and Transplantation, Norton Thoracic Institute, Phoenix, AZ, USA.
Rajat Walia
5Department of Thoracic Disease and Transplantation, Norton Thoracic Institute, Phoenix, AZ, USA.
Timothy S. Blackwell
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
6Department of Veterans Affairs Medical Center, Nashville, TN, USA.
11Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Nicholas E. Banovich
2Translational Genomics Research Institute, Phoenix, AZ, USA.
Jonathan A. Kropski
1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
6Department of Veterans Affairs Medical Center, Nashville, TN, USA.
11Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
