Contents
July 2020
Vol 6, Issue 29
Vol 6, Issue 29
Contents
Research Articles
- Wise or mad crowds? The cognitive mechanisms underlying information cascades
The integration of personal and social information dynamically over time gives rise to beneficial information cascades.
- Aerosol-forced multidecadal variations across all ocean basins in models and observations since 1920
Have volcanic and anthropogenic aerosols contributed to AMO-like multidecadal climate variations across the globe?
- Preserved visual memory and relational cognition performance in monkeys with selective hippocampal lesions
On a wide battery of cognitive tasks predicted to be hippocampally dependent, monkeys with hippocampal damage performed normally.
- Helicity-dependent photocurrents in the chiral Weyl semimetal RhSi
The CPGE spectrum and optical conductivity in RhSi are measured and discussed, comparing to theoretical predictions.
- Co-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer
Co-delivery of IKBKE siRNA and cabazitaxel inhibits invasiveness and growth of triple-negative breast cancer.
- Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis
Retroviral protein, expressed in patients with psychotic disorders, corrupts the development of excitatory synapses and behavior.
- De novo rational design of a freestanding, supercharged polypeptide, proton-conducting membrane
Innovative bio-inspired device based on supercharged spider silk nanostructures engineered to efficiently transport protons.
- High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles
Superparamagnetic nanoparticles will boost image contrast on portable MRI scanners operating at low magnetic fields.
- Future precipitation increase from very high resolution ensemble downscaling of extreme atmospheric river storms in California
California’s most intense atmospheric river storms will bring increasingly extreme precipitation in a warming climate.
- An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging
A metal cluster stuck in a protein acts as a synthetic metalloenzyme for cancer-specific catalytic therapy.
- Purely satellite data–driven deep learning forecast of complicated tropical instability waves
We developed a deep learning model to forecast the sea surface temperature evolution associated with tropical instability waves.
- Strain engineering of the magnetic multipole moments and anomalous Hall effect in pyrochlore iridate thin films
Strain-engineered magnetic multipole moments can generate novel anomalous Hall effect in antiferromagnetic oxide thin films.
- β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus
β-Catenin recruits BRD4 and other coregulators to protect pluripotency gene transcription against network perturbation.
- Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects
Engineered base editors convert the second nucleotide C to T in the context of 5′-CC-3′ with high precision and targeting fidelity.
- Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4+ T cells ex vivo
Polo-like kinase 1 (PLK1) inhibitors have the potential to eliminate the latent HIV-1 in AIDS patients.
- RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma
RACK7 recognizes H3.3G34R to suppress expression of MHC II complex components and their delivery pathway in pediatric GBM.
- Compact nanoscale textures reduce contact time of bouncing droplets
Compact nanoscale textures reduce contact time of bouncing droplets with implications in insect survival and miniature drones.
- Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy
We designed a cascade nanozyme with both superoxide dismutase– and catalase-mimicking activities for anti-inflammation therapy.
- ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression
ARID1A is a tumor suppressor in neuroblastoma, whose loss promotes the adrenergic-to-mesenchymal transition.
- GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production
Mice lacking the enzyme GADL1 have reduced levels of carnosine and anserine peptides and increased oxidative stress markers.
- Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects
Codelivery of CRISPR-Cas9 and chlorin e6 achieved spatially controlled tumor-specific gene editing with synergistic drug effects.
- A positive, growth-based PAM screen identifies noncanonical motifs recognized by the S. pyogenes Cas9
SpyCas9 and its engineered variants can recognize NYGG PAMs, affecting their use for genome editing and off-target predictions.
- Molding free-space light with guided wave–driven metasurfaces
A guided wave–driven metasurface directly extracts and molds light from a waveguide into arbitrarily complex free-space modes.
- Magnetic levitational bioassembly of 3D tissue construct in space
Magnetic levitation is used for 3D biomanufacturing and biofabrication in space.
- Self-healable sticky porous elastomer for gas-solid interacted power generation
Gas-solid electrification enabled by a sticky porous elastomer.
- A customized belonging intervention improves retention of socially disadvantaged students at a broad-access university
Bolstering belonging at a broad-access university improves persistence.
- Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor
Allosteric communication pathways in the glucocorticoid receptor ligand-binding domain respond to ligand structure.
- Targeting brain metastases with ultrasmall theranostic nanoparticles, a first-in-human trial from an MRI perspective
Intravenously injected theranostic Gd-based nanoparticles enable targeting and MRI detection of brain metastases in patients.
- Crystal structure of the human oxytocin receptor
Human oxytocin receptor structure reveals the basis for ligand recognition and allosteric modulation by lipids and ions.
- Evaluating the impact of long-term exposure to fine particulate matter on mortality among the elderly
Long-term exposure to fine particulate matter positively affects all-cause mortality among the elderly.
- The evolution of infant mortality inequality in the United States, 1960–2016
Infant mortality inequality in the United States decreased meaningfully between 1960 and 2000 but remained constant between 2000 and 2016.
- The shape of educational inequality
The ability of community college students to be successful is conceptualized, measured, and shown to be exponentially distributed.
- Pre-Clovis occupation of the Americas identified by human fecal biomarkers in coprolites from Paisley Caves, Oregon
We unequivocally confirmed pre-Clovis human occupation of the western Great Basin using fecal lipid biomarkers and a new 14C date.
- Probing quantum walks through coherent control of high-dimensionally entangled photons
Demonstrating continuously tunable photonic quantum walks in the frequency domain with high-dimensionally entangled photon pairs.
- Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies
Cryo-EM structures reveal the ATP conduction and oligomeric assembly mechanisms of CALHM channels.
- Cryo-EM structure of the calcium homeostasis modulator 1 channel
The cryo-EM structure of the CALHM1 channel reveals an octameric assembly and nearly the entire N terminus inside the pore.
- p-type transparent superconductivity in a layered oxide
Strongly correlated electrons confined in two-dimensional NbO6 triangular prism layers create a p-type transparent superconductor.
- Reconfigurable Floquet elastodynamic topological insulator based on synthetic angular momentum bias
Spatiotemporally modulated array of piezoelectric patches implements a Floquet topological insulator for elastic waves.
- Active microrheology of a bulk metallic glass
A probe particle driven into a supercooled liquid reveals the structural properties of the host medium.
- Ocean currents promote rare species diversity in protists
Transport by ocean currents contributes to the diversity of planktonic species observed in metagenomic studies.
- A reanalysis of nanoparticle tumor delivery using classical pharmacokinetic metrics
Interpretation of nanoparticle PK results can be markedly influenced by differing PK metrics selected.
- Nutrient ratios in marine particulate organic matter are predicted by the population structure of well-adapted phytoplankton
Global patterns in organic matter stoichiometry are predicted by the population structure of well-adapted phytoplankton.
- High-frequency hearing in a hummingbird
A hummingbird can hear high-pitched sounds that most birds cannot perceive.
- Cell invasion in digital microfluidic microgel systems
A digital microfluidic technique allows for analysis of sub-populations of invading cells by transcriptomics.
Review
- Beyond the cell factory: Homeostatic regulation of and by the UPRER
The UPRER is generally considered a protein homeostasis machinery, but this review uncovers many additional functions of UPRER.
About The Cover
ONLINE COVER Broad-access institutions accept more than 75% of applicants and serve many first-generation college students and racial and ethnic minority students. But although these institutions provide valuable educational opportunities for disadvantaged groups, they are also plagued by low graduation rates. To investigate whether concerns about belonging (combined with financial constraints and lower levels of academic preparedness) may undermine student success at these institutions, Murphy et al. tested the impact of a customized reading and writing exercise administered to 1,063 first-year students at a midwestern broad-access public university with a high Hispanic population. While similar exercises have been tested at more selective universities with high admission standards, past assessments have tended not to focus on broad-access institutions. The researchers found that the brief exercise raised continuous enrollment over 2 years by 9% among socially disadvantaged students and helped their GPAs to increase by 0.19 points in the semester following their participation in the exercise. [CREDIT: SKYNESHER/ISTOCK]
