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A reanalysis of nanoparticle tumor delivery using classical pharmacokinetic metrics

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Science Advances  15 Jul 2020:
Vol. 6, no. 29, eaay9249
DOI: 10.1126/sciadv.aay9249

Article Information

vol. 6 no. 29

Online ISSN: 
  • Received for publication July 30, 2019
  • Accepted for publication May 29, 2020
  • .

Author Information

  1. Lauren S. L. Price1,2,*,
  2. Stephan T. Stern3,
  3. Allison M. Deal4,
  4. Alexander V. Kabanov1,5,6,7 and
  5. William C. Zamboni1,2,5,6,7,
  1. 1Carolina Center of Cancer Nanotechnology Excellence (C-CCNE), University of North Carolina, Chapel Hill, NC, USA.
  2. 2Translational Oncology and Nanoparticle Drug Development (TOND2I) Lab, University of North Carolina, Chapel Hill, NC, USA.
  3. 3Nanotechnology Characterization Lab (NCL), Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  4. 4UNC Lineberger Biostatistics Shared Resource, Chapel Hill, NC, USA.
  5. 5UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
  6. 6Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA.
  7. 7Carolina Institute for Nanomedicine, University of North Carolina, Chapel Hill, NC, USA.
  1. Corresponding author. Email: zamboni{at}
  • * Present address: Division of Cancer Pharmacology II, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.


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