Research ArticleVIROLOGY

Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4+ T cells ex vivo

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Science Advances  15 Jul 2020:
Vol. 6, no. 29, eaba1941
DOI: 10.1126/sciadv.aba1941

Article Information

vol. 6 no. 29

Online ISSN: 
History: 
  • Received for publication December 14, 2019
  • Accepted for publication May 14, 2020
  • .

Author Information

  1. Dawei Zhou1,
  2. Tsuyoshi Hayashi2,*,
  3. Maxime Jean2,
  4. Weili Kong1,,
  5. Guillaume Fiches1,
  6. Ayan Biswas1,
  7. Shuai Liu3,
  8. Hailemichael O. Yosief3,
  9. Xiaofeng Zhang3,
  10. Jay Bradner4,
  11. Jun Qi5,
  12. Wei Zhang3,
  13. Netty Santoso1 and
  14. Jian Zhu1,
  1. 1Department of Pathology, Ohio State University College of Medicine, Columbus, OH 43210, USA.
  2. 2Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester NY 14642, USA.
  3. 3Chemistry Department, College of Science and Mathematics, University of Massachusetts at Boston, Boston, MA 02125, USA.
  4. 4Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
  5. 5Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: jian.zhu{at}osumc.edu
  • * Present address: National Institute of Infectious Diseases, Tokyo 162-8640, Japan.

  • Present address: Gladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA 94158, USA.

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