Research ArticleHEALTH AND MEDICINE
An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging
- View ORCID ProfileLiang Gao1,*,
- View ORCID ProfileYa Zhang1,*,
- View ORCID ProfileLina Zhao2,†,
- Wenchao Niu1,
- Yuhua Tang1,
- View ORCID ProfileFuping Gao2,
- Pengju Cai2,
- View ORCID ProfileQing Yuan1,
- View ORCID ProfileXiayan Wang1,
- View ORCID ProfileHuaidong Jiang3 and
- View ORCID ProfileXueyun Gao1,†
- 1Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
- 2CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
- 3School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
- ↵†Corresponding author. Email: gaoxy{at}ihep.ac.cn (X. G.); linazhao{at}ihep.ac.cn (L. Z.)
↵* These authors contributed equally to this work.
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Science Advances 15 Jul 2020:
Vol. 6, no. 29, eabb1421
DOI: 10.1126/sciadv.abb1421
Vol. 6, no. 29, eabb1421
DOI: 10.1126/sciadv.abb1421
Liang Gao
1Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Ya Zhang
1Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Lina Zhao
2CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Wenchao Niu
1Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Yuhua Tang
1Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Fuping Gao
2CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Pengju Cai
2CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Qing Yuan
1Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Xiayan Wang
1Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
Huaidong Jiang
3School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Xueyun Gao
1Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
