Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Yufeng Liu; Yuan Cheng; He Zhang; Min Zhou; Yijun Yu; Shichao Lin; Bo Jiang; Xiaozhi Zhao; Leiying Miao; Chuan-Wan Wei; Quanyi Liu; Ying-Wu Lin; Yan Du; Christopher J. Butch; Hui Wei

doi:10.1126/sciadv.abb2695

Research ArticleHEALTH AND MEDICINE

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

View ORCID ProfileYufeng Liu¹,*,
View ORCID ProfileYuan Cheng ¹,*,
View ORCID ProfileHe Zhang²,
Min Zhou¹,
View ORCID ProfileYijun Yu³,
View ORCID ProfileShichao Lin¹,
Bo Jiang⁴,
Xiaozhi Zhao⁴,
View ORCID ProfileLeiying Miao³,
Chuan-Wan Wei⁵,
Quanyi Liu⁶,
View ORCID ProfileYing-Wu Lin⁵,
View ORCID ProfileYan Du⁶,
View ORCID ProfileChristopher J. Butch¹,† and
View ORCID ProfileHui Wei ¹,⁷,⁸,†

¹Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.
²Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.
³Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.
⁴Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu 210008 China.
⁵Laboratory of Protein Structure and Function, School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China.
⁶State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China.
⁷Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210093, China.
⁸State Key Laboratory of Analytical Chemistry for Life Science and State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu 210023, China.

↵†Corresponding author. Email: weihui{at}nju.edu.cn (H.W.); chrisbutch{at}gmail.com (C.J.B.)

↵* These authors contributed equally to this work.

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Science Advances 17 Jul 2020:
Vol. 6, no. 29, eabb2695
DOI: 10.1126/sciadv.abb2695

Yufeng Liu

1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.

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Yuan Cheng

1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.

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He Zhang

2Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.

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Min Zhou

1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.

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Yijun Yu

3Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.

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Shichao Lin

1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.

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Bo Jiang

4Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu 210008 China.

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Xiaozhi Zhao

4Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu 210008 China.

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Leiying Miao

3Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.

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Chuan-Wan Wei

5Laboratory of Protein Structure and Function, School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China.

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Quanyi Liu

6State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China.

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Ying-Wu Lin

5Laboratory of Protein Structure and Function, School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China.

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Yan Du

6State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China.

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Christopher J. Butch

1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.

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For correspondence: weihui@nju.edu.cn chrisbutch@gmail.com

Hui Wei

1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.

7Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210093, China.

8State Key Laboratory of Analytical Chemistry for Life Science and State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu 210023, China.

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ORCID record for Hui Wei
For correspondence: weihui@nju.edu.cn chrisbutch@gmail.com

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