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Research ArticleHEALTH AND MEDICINE
Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy
- View ORCID ProfileYufeng Liu1,*,
- View ORCID ProfileYuan Cheng1,*,
- View ORCID ProfileHe Zhang2,
- Min Zhou1,
- View ORCID ProfileYijun Yu3,
- View ORCID ProfileShichao Lin1,
- Bo Jiang4,
- Xiaozhi Zhao4,
- View ORCID ProfileLeiying Miao3,
- Chuan-Wan Wei5,
- Quanyi Liu6,
- View ORCID ProfileYing-Wu Lin5,
- View ORCID ProfileYan Du6,
- View ORCID ProfileChristopher J. Butch1,† and
- View ORCID ProfileHui Wei1,7,8,†
- 1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.
- 2Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.
- 3Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.
- 4Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu 210008 China.
- 5Laboratory of Protein Structure and Function, School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China.
- 6State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China.
- 7Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210093, China.
- 8State Key Laboratory of Analytical Chemistry for Life Science and State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu 210023, China.
- ↵†Corresponding author. Email: weihui{at}nju.edu.cn (H.W.); chrisbutch{at}gmail.com (C.J.B.)
↵* These authors contributed equally to this work.
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Science Advances 17 Jul 2020:
Vol. 6, no. 29, eabb2695
DOI: 10.1126/sciadv.abb2695
Vol. 6, no. 29, eabb2695
DOI: 10.1126/sciadv.abb2695
Yufeng Liu
1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.
Yuan Cheng
1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.
He Zhang
2Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.
Min Zhou
1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.
Yijun Yu
3Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.
Shichao Lin
1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.
Bo Jiang
4Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu 210008 China.
Xiaozhi Zhao
4Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu 210008 China.
Leiying Miao
3Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, China.
Chuan-Wan Wei
5Laboratory of Protein Structure and Function, School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China.
Quanyi Liu
6State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China.
Ying-Wu Lin
5Laboratory of Protein Structure and Function, School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China.
Yan Du
6State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China.
Christopher J. Butch
1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.
Hui Wei
1Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China.
7Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210093, China.
8State Key Laboratory of Analytical Chemistry for Life Science and State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu 210023, China.
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