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Structure-guided discovery of a single-domain antibody agonist against human apelin receptor

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Science Advances  15 Jan 2020:
Vol. 6, no. 3, eaax7379
DOI: 10.1126/sciadv.aax7379

Article Information

vol. 6 no. 3

Online ISSN: 
History: 
  • Received for publication April 17, 2019
  • Accepted for publication October 29, 2019
  • .

Author Information

  1. Yanbin Ma1,
  2. Yao Ding1,
  3. Xianqiang Song1,
  4. Xiaochuan Ma1,
  5. Xun Li1,
  6. Ning Zhang1,
  7. Yunpeng Song1,
  8. Yaping Sun1,
  9. Yuqing Shen2,
  10. Wenge Zhong1,*,
  11. Liaoyuan A. Hu1,
  12. Yingli Ma1 and
  13. Mei-Yun Zhang1,
  1. 1Amgen Discovery Research, Amgen Asia R&D Center, Amgen Biopharmaceutical R&D (Shanghai) Co. Ltd., 13th Floor, Building No. 2, 4560 Jinke Road, Zhangjiang, Shanghai 201210, China.
  2. 2Therapeutic Discovery, Amgen Inc., One Amgen Center Dr., Thousand Oaks, CA 91320, USA.
  1. Corresponding author. Email: meiyunz{at}amgen.com
  • * Present address: Regor Therapeutics Inc., Building C, Kechuang Yuan, 1206 Zhangjiang Road, Shanghai 201210, China.

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