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Research ArticleHEALTH AND MEDICINE
Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists
- View ORCID ProfileJiaxuan Chen1,2,
- Carolyn A. Haller1,2,
- View ORCID ProfileFinith E. Jernigan1,
- Steffi K. Koerner1,
- View ORCID ProfileDaniel J. Wong1,
- Yiqiang Wang1,
- Jae Eun Cheong1,
- Revanth Kosaraju1,
- View ORCID ProfileJulian Kwan3,
- View ORCID ProfileDiane D. Park1,2,
- Beena Thomas4,
- View ORCID ProfileSwati Bhasin4,
- View ORCID ProfileRoberto C. De La Rosa1,5,
- Alykhan M. Premji1,
- Liying Liu1,
- Eden Park6,
- View ORCID ProfileAlan C. Moss6,
- View ORCID ProfileAndrew Emili3,
- Manoj Bhasin4,
- View ORCID ProfileLijun Sun1,*,† and
- View ORCID ProfileElliot L. Chaikof1,2,*,†
- 1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
- 2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.
- 3Department of Biology and Biochemistry, Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA.
- 4BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
- 5Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
- 6Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
- ↵*Corresponding author. Email: echaikof{at}bidmc.harvard.edu (E.L.C); lsun1{at}bidmc.harvard.edu (L.S.)
↵† These authors contributed equally to this work.
See allHide authors and affiliations
Science Advances 15 Jan 2020:
Vol. 6, no. 3, eaay8230
DOI: 10.1126/sciadv.aay8230
Vol. 6, no. 3, eaay8230
DOI: 10.1126/sciadv.aay8230
Jiaxuan Chen
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.
Carolyn A. Haller
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.
Finith E. Jernigan
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Steffi K. Koerner
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Daniel J. Wong
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Yiqiang Wang
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Jae Eun Cheong
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Revanth Kosaraju
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Julian Kwan
3Department of Biology and Biochemistry, Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA.
Diane D. Park
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.
Beena Thomas
4BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Swati Bhasin
4BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Roberto C. De La Rosa
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
5Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Alykhan M. Premji
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Liying Liu
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Eden Park
6Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Alan C. Moss
6Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Andrew Emili
3Department of Biology and Biochemistry, Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA.
Manoj Bhasin
4BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Lijun Sun
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Elliot L. Chaikof
1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.
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