Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists

Jiaxuan Chen; Carolyn A. Haller; Finith E. Jernigan; Steffi K. Koerner; Daniel J. Wong; Yiqiang Wang; Jae Eun Cheong; Revanth Kosaraju; Julian Kwan; Diane D. Park; Beena Thomas; Swati Bhasin; Roberto C. De La Rosa; Alykhan M. Premji; Liying Liu; Eden Park; Alan C. Moss; Andrew Emili; Manoj Bhasin; Lijun Sun; Elliot L. Chaikof

doi:10.1126/sciadv.aay8230

Research ArticleHEALTH AND MEDICINE

Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists

View ORCID ProfileJiaxuan Chen¹,²,
Carolyn A. Haller¹,²,
View ORCID ProfileFinith E. Jernigan¹,
Steffi K. Koerner¹,
View ORCID ProfileDaniel J. Wong ¹,
Yiqiang Wang¹,
Jae Eun Cheong¹,
Revanth Kosaraju¹,
View ORCID ProfileJulian Kwan³,
View ORCID ProfileDiane D. Park¹,²,
Beena Thomas⁴,
View ORCID ProfileSwati Bhasin⁴,
View ORCID ProfileRoberto C. De La Rosa ¹,⁵,
Alykhan M. Premji ¹,
Liying Liu¹,
Eden Park⁶,
View ORCID ProfileAlan C. Moss⁶,
View ORCID ProfileAndrew Emili³,
Manoj Bhasin⁴,
View ORCID ProfileLijun Sun¹,*,† and
View ORCID ProfileElliot L. Chaikof¹,²,*,†

¹Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
²Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.
³Department of Biology and Biochemistry, Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA.
⁴BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
⁵Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
⁶Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

↵*Corresponding author. Email: echaikof{at}bidmc.harvard.edu (E.L.C); lsun1{at}bidmc.harvard.edu (L.S.)

↵† These authors contributed equally to this work.

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Science Advances 15 Jan 2020:
Vol. 6, no. 3, eaay8230
DOI: 10.1126/sciadv.aay8230

Jiaxuan Chen

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.

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ORCID record for Jiaxuan Chen

Carolyn A. Haller

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.

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Finith E. Jernigan

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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ORCID record for Finith E. Jernigan

Steffi K. Koerner

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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Daniel J. Wong

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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Yiqiang Wang

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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Jae Eun Cheong

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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Revanth Kosaraju

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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Julian Kwan

3Department of Biology and Biochemistry, Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA.

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Diane D. Park

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.

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Beena Thomas

4BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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Swati Bhasin

4BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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Roberto C. De La Rosa

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

5Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.

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Alykhan M. Premji

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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Liying Liu

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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Eden Park

6Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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Alan C. Moss

6Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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Andrew Emili

3Department of Biology and Biochemistry, Center for Network Systems Biology, Boston University School of Medicine, Boston, MA 02118, USA.

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Manoj Bhasin

4BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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Lijun Sun

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

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For correspondence: echaikof@bidmc.harvard.edu lsun1@bidmc.harvard.edu

Elliot L. Chaikof

1Department of Surgery, Center for Drug Discovery and Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

2Wyss Institute of Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA.

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ORCID record for Elliot L. Chaikof
For correspondence: echaikof@bidmc.harvard.edu lsun1@bidmc.harvard.edu

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