Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease

E. Hossain; S. Khanam; D. A. Dean; C. Wu; S. Lostracco-Johnson; D. Thomas; S. S. Kane; A. R. Parab; K. Flores; M. Katemauswa; C. Gosmanov; S. E. Hayes; Y. Zhang; D. Li; C. Woelfel-Monsivais; K. Sankaranarayanan; L.-I. McCall

doi:10.1126/sciadv.aaz2015

Research ArticleMICROBIOLOGY

Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease

View ORCID ProfileE. Hossain¹,²,
View ORCID ProfileS. Khanam²,³,
View ORCID ProfileD. A. Dean¹,²,
C. Wu¹,²,
S. Lostracco-Johnson⁴,
D. Thomas⁴,
View ORCID ProfileS. S. Kane¹,²,
A. R. Parab²,³,
K. Flores²,⁵,
View ORCID ProfileM. Katemauswa¹,²,
C. Gosmanov¹,²,
S. E. Hayes¹,
Y. Zhang¹,
View ORCID ProfileD. Li⁶,
View ORCID ProfileC. Woelfel-Monsivais²,³,
View ORCID ProfileK. Sankaranarayanan ²,³,* and
View ORCID ProfileL.-I. McCall ¹,²,³,*

¹Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
²Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.
³Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USA.
⁴Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
⁵Department of Biology, University of Oklahoma, Norman, OK 73019, USA.
⁶College of Chemistry, Beijing Normal University, Beijing 100875, China.

↵*Corresponding author. Email: ksankar{at}ou.edu (K.S.); lmccall{at}ou.edu (L.-I.M.)

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Science Advances 22 Jul 2020:
Vol. 6, no. 30, eaaz2015
DOI: 10.1126/sciadv.aaz2015

E. Hossain

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

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S. Khanam

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

3Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USA.

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D. A. Dean

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

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C. Wu

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

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S. Lostracco-Johnson

4Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

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D. Thomas

4Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

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S. S. Kane

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

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A. R. Parab

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

3Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USA.

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K. Flores

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

5Department of Biology, University of Oklahoma, Norman, OK 73019, USA.

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M. Katemauswa

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

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C. Gosmanov

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

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S. E. Hayes

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

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Y. Zhang

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

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D. Li

6College of Chemistry, Beijing Normal University, Beijing 100875, China.

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C. Woelfel-Monsivais

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

3Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USA.

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K. Sankaranarayanan

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

3Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USA.

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For correspondence: ksankar@ou.edu lmccall@ou.edu

L.-I. McCall

1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.

2Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019, USA.

3Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USA.

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For correspondence: ksankar@ou.edu lmccall@ou.edu

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Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease

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