Research ArticleCANCER

Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning

See allHide authors and affiliations

Science Advances  24 Jul 2020:
Vol. 6, no. 30, eaaz6197
DOI: 10.1126/sciadv.aaz6197

Article Information

vol. 6 no. 30

Online ISSN: 
History: 
  • Received for publication October 8, 2019
  • Accepted for publication June 11, 2020
  • .

Author Information

  1. Emily R. Summerbell1,*,
  2. Janna K. Mouw2,3,*,
  3. Joshua S. K. Bell4,,
  4. Christina M. Knippler2,3,
  5. Brian Pedro1,
  6. Jamie L. Arnst2,3,
  7. Tala O. Khatib5,
  8. Rachel Commander1,
  9. Benjamin G. Barwick2,3,
  10. Jessica Konen1,,
  11. Bhakti Dwivedi3,
  12. Sandra Seby3,
  13. Jeanne Kowalski3,6,§,
  14. Paula M. Vertino3,7,||, and
  15. Adam I. Marcus2,3,#
  1. 1Graduate Program in Cancer Biology, Emory University, Atlanta, GA, USA.
  2. 2Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
  3. 3Winship Cancer Institute, Emory University, Atlanta, GA, USA.
  4. 4Graduate Program in Genetics and Molecular Biology, Emory University, Atlanta, GA, USA.
  5. 5Graduate Program in Biochemistry, Cell and Developmental Biology, Emory University, Atlanta, GA, USA.
  6. 6Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
  7. 7Department of Radiation Oncology, Emory University, Atlanta, GA, USA.
  1. #Corresponding author. Email: aimarcu{at}emory.edu
  • * These authors contributed equally to this work.

  • Present address: Tempus Labs Inc., Chicago, IL, USA.

  • Present address: Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

  • § Present address: Department of Oncology, The University of Texas at Austin, Dell Medical School, Austin, TX, USA.

  • || Present address: Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

  • Present address: Wilmot Cancer Institute, Rochester, NY, USA.

Altmetric

Article usage

Article usage: July 2020 to October 2020

AbstractFullPdf
Jul 20201062057418
Aug 202028572174
Sep 20209370125
Oct 2020425897

Stay Connected to Science Advances

Navigate This Article