Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB–VCAM-1 axis

See allHide authors and affiliations

Science Advances  29 Jul 2020:
Vol. 6, no. 31, eaaz7815
DOI: 10.1126/sciadv.aaz7815

Article Information

vol. 6 no. 31

Online ISSN: 
  • Received for publication October 8, 2019
  • Accepted for publication June 16, 2020
  • .

Author Information

  1. Yue Li1,
  2. Ahmad M. N. Alhendi1,
  3. Mei-Chun Yeh1,
  4. Mina Elahy1,
  5. Fernando S. Santiago1,
  6. Nandan P. Deshpande2,
  7. Ben Wu1,
  8. Enoch Chan1,
  9. Shafqat Inam1,
  10. Leonel Prado-Lourenco1,
  11. Jessica Marchand3,
  12. Rohan D. Joyce3,
  13. Lorna E. Wilkinson-White4,
  14. Mark J. Raftery5,
  15. Meidong Zhu6,7,8,
  16. Samuel J. Adamson8,
  17. François Barnat9,
  18. Karen Viaud-Quentric9,
  19. Jim Sockler10,
  20. Joel P. Mackay11,
  21. Andrew Chang7,8,12,
  22. Paul Mitchell13,
  23. Sebastian M. Marcuccio3,14 and
  24. Levon M. Khachigian1,*
  1. 1Vascular Biology and Translational Research, School of Medical Sciences and UNSW Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
  2. 2Systems Biology Initiative, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
  3. 3Advanced Molecular Technologies Pty Ltd, Scoresby, VIC 3179, Australia.
  4. 4Sydney Analytical Core Facility, University of Sydney, NSW 2006, Australia.
  5. 5Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, NSW 2052, Australia.
  6. 6New South Wales Tissue Bank, New South Wales Organ and Tissue Donation Service, South Eastern Sydney Local Health District, Kogarah, NSW 2217, Australia.
  7. 7Save Sight Institute, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, NSW 2006, Australia.
  8. 8GreenLight Clinical Pty. Ltd., Woolloomooloo, NSW 2011, Australia.
  9. 9Iris Pharma, La Gaude 06610, France.
  10. 10Statistical Operations and Programming, Datapharm Australia Pty. Ltd., Drummoyne, NSW 2047, Australia.
  11. 11School of Life and Environmental Sciences, University of Sydney, NSW 2006, Australia.
  12. 12Sydney Eye Hospital, Sydney NSW 2000 and University of Sydney, NSW 2006, Australia.
  13. 13Centre for Vision Research, Department of Ophthalmology, Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia.
  14. 14La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
  1. *Corresponding author. Email: l.khachigian{at}


Article usage

Article usage: July 2020 to September 2020

Jul 2020911230200
Aug 2020741850195
Sep 2020752565

Stay Connected to Science Advances

Navigate This Article