Research ArticleGENETICS

Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

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Science Advances  29 Jul 2020:
Vol. 6, no. 31, eaba5345
DOI: 10.1126/sciadv.aba5345

Article Information

vol. 6 no. 31

PubMed: 
Online ISSN: 
History: 
  • Received for publication December 11, 2019
  • Accepted for publication June 17, 2020
  • .

Author Information

  1. Ana Victoria Lechuga-Vieco1,2,*,,
  2. Ana Latorre-Pellicer1,3,*,
  3. Iain G. Johnston4,
  4. Gennaro Prota5,
  5. Uzi Gileadi5,
  6. Raquel Justo-Méndez1,
  7. Rebeca Acín-Pérez1,
  8. Raquel Martínez-de-Mena1,
  9. Jose María Fernández-Toro1,
  10. Daniel Jimenez-Blasco6,7,8,
  11. Alfonso Mora1,
  12. Jose A. Nicolás-Ávila1,
  13. Demetrio J. Santiago1,9,10,
  14. Silvia G. Priori1,9,10,
  15. Juan Pedro Bolaños6,7,8,
  16. Guadalupe Sabio1,
  17. Luis Miguel Criado1,
  18. Jesús Ruíz-Cabello2,11,12,13,
  19. Vincenzo Cerundolo5,
  20. Nick S. Jones14 and
  21. José Antonio Enríquez1,8,
  1. 1Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
  2. 2CIBERES: C/ Melchor Fernández-Almagro 3, 28029 Madrid, Spain.
  3. 3Unit of Clinical Genetics and Functional Genomics, Department of Pharmacology-Physiology, School of Medicine, University of Zaragoza, IIS Aragon, E-50009 Zaragoza, Spain.
  4. 4Department of Mathematics, Faculty of Mathematics and Natural Sciences, University of Bergen, Bergen, Norway.
  5. 5MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  6. 6IBFG, Universidad de Salamanca, Salamanca, Spain.
  7. 7IBSAL, Hospital Universitario de Salamanca, Universidad de Salamanca, CSIC, Salamanca, Spain.
  8. 8CIBERFES, C/Melchor Fernández-Almagro 3, 28029 Madrid, Spain.
  9. 9Molecular Cardiology, IRCCS ICS Maugeri, Pavia, Italy.
  10. 10Department of Molecular Medicine, University of Pavia, Pavia, Italy.
  11. 11CIC biomaGUNE 20014 Donostia/San Sebastián, Gipuzkoa, Spain.
  12. 12IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
  13. 13Universidad Complutense Madrid, Madrid, Spain.
  14. 14EPSRC Centre for the Mathematics of Precision Healthcare, Department of Mathematics, Imperial College London, London SW7 2BB, UK.
  1. Corresponding author. Email: jaenriquez{at}cnic.es
  • * These authors contributed equally to this work.

  • Present address: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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