Research ArticleIMMUNOLOGY

IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

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Science Advances  29 Jul 2020:
Vol. 6, no. 31, eabb0806
DOI: 10.1126/sciadv.abb0806

Article Information

vol. 6 no. 31

Online ISSN: 
History: 
  • Received for publication January 28, 2020
  • Accepted for publication June 11, 2020
  • .

Author Information

  1. Maha Almanan1,
  2. Jana Raynor1,*,
  3. Ireti Ogunsulire2,
  4. Anna Malyshkina1,
  5. Shibabrata Mukherjee1,
  6. Sarah A. Hummel1,
  7. Jennifer T. Ingram3,
  8. Ankur Saini1,4,
  9. Markus M. Xie5,
  10. Theresa Alenghat1,4,6,
  11. Sing Sing Way6,7,
  12. George S. Deepe Jr.5,
  13. Senad Divanovic1,
  14. Harinder Singh1,4,
  15. Emily Miraldi1,4,
  16. Allan J. Zajac3,
  17. Alexander L. Dent8,
  18. Christoph Hölscher2,
  19. Claire Chougnet1,4 and
  20. David A. Hildeman1,4,
  1. 1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  2. 2Division of Infection Immunology, Research Center Borstel, Borstel, Germany.
  3. 3Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  4. 4Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
  5. 5Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
  6. 6Center for Inflammation and Tolerance, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
  7. 7Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
  8. 8Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  1. Corresponding author. Email: david.hildeman{at}cchmc.org
  • * Present address: St. Jude Children’s Research Hospital, 262 Danny Thomas Place Memphis, TN 38105, USA.

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