Research ArticleIMMUNOLOGY
IL-10–producing Tfh cells accumulate with age and link inflammation with age-related immune suppression
- View ORCID ProfileMaha Almanan1,
- Jana Raynor1,*,
- Ireti Ogunsulire2,
- View ORCID ProfileAnna Malyshkina1,
- Shibabrata Mukherjee1,
- Sarah A. Hummel1,
- Jennifer T. Ingram3,
- View ORCID ProfileAnkur Saini1,4,
- View ORCID ProfileMarkus M. Xie5,
- View ORCID ProfileTheresa Alenghat1,4,6,
- View ORCID ProfileSing Sing Way6,7,
- George S. Deepe Jr.5,
- View ORCID ProfileSenad Divanovic1,
- View ORCID ProfileHarinder Singh1,4,
- View ORCID ProfileEmily Miraldi1,4,
- Allan J. Zajac3,
- View ORCID ProfileAlexander L. Dent8,
- Christoph Hölscher2,
- Claire Chougnet1,4 and
- View ORCID ProfileDavid A. Hildeman1,4,†
- 1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
- 2Division of Infection Immunology, Research Center Borstel, Borstel, Germany.
- 3Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- 4Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
- 5Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
- 6Center for Inflammation and Tolerance, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
- 7Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
- 8Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- ↵†Corresponding author. Email: david.hildeman{at}cchmc.org
↵* Present address: St. Jude Children’s Research Hospital, 262 Danny Thomas Place Memphis, TN 38105, USA.
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Science Advances 29 Jul 2020:
Vol. 6, no. 31, eabb0806
DOI: 10.1126/sciadv.abb0806
Vol. 6, no. 31, eabb0806
DOI: 10.1126/sciadv.abb0806
Maha Almanan
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Jana Raynor
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Ireti Ogunsulire
2Division of Infection Immunology, Research Center Borstel, Borstel, Germany.
Anna Malyshkina
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Shibabrata Mukherjee
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Sarah A. Hummel
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Jennifer T. Ingram
3Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ankur Saini
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
4Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
Markus M. Xie
5Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Theresa Alenghat
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
4Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
6Center for Inflammation and Tolerance, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
Sing Sing Way
6Center for Inflammation and Tolerance, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
7Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
George S. Deepe Jr.
5Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Senad Divanovic
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Harinder Singh
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
4Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
Emily Miraldi
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
4Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
Allan J. Zajac
3Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Alexander L. Dent
8Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Christoph Hölscher
2Division of Infection Immunology, Research Center Borstel, Borstel, Germany.
Claire Chougnet
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
4Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.
David A. Hildeman
1Division of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
4Center for Systems Immunology, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA.