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A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems

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Science Advances  29 Jul 2020:
Vol. 6, no. 31, eabb6651
DOI: 10.1126/sciadv.abb6651

Article Information

vol. 6 no. 31

PubMed: 
Online ISSN: 
History: 
  • Received for publication March 10, 2020
  • Accepted for publication June 12, 2020
  • .

Author Information

  1. Yiming Cai1,*,
  2. Ben Usher2,*,
  3. Claude Gutierrez3,
  4. Anastasia Tolcan4,
  5. Moise Mansour1,
  6. Peter C. Fineran5,6,7,
  7. Ciarán Condon4,
  8. Olivier Neyrolles3,
  9. Pierre Genevaux1,, and
  10. Tim R. Blower2,,
  1. 1Laboratoire de Microbiologie et Génétique Moléculaires, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31400 Toulouse, France.
  2. 2Department of Biosciences, Durham University, South Road, Durham DH1 3LE, UK.
  3. 3Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, 205 route de Narbonne, 31400 Toulouse, France.
  4. 4UMR8261 (CNRS, Université de Paris), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.
  5. 5Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
  6. 6Genetics Otago, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
  7. 7Bio-protection Research Centre, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
  1. Corresponding author. Email: genevaux{at}ibcg.biotoul.fr (P.G.), timothy.blower{at}durham.ac.uk (T.R.B.)
  • * These authors contributed equally to this work.

  • Co–senior authors.

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