Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia

Hee Ho Park; Hong Nam Kim; Hyelim Kim; Youngbum Yoo; Hyosoo Shin; Eun Young Choi; Jong-Sup Bae; Wonhwa Lee

doi:10.1126/sciadv.abc1564

Research ArticleCORONAVIRUS

Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia

View ORCID ProfileHee Ho Park ¹,*,
View ORCID ProfileHong Nam Kim ²,³,*,
View ORCID ProfileHyelim Kim⁴,*,
Youngbum Yoo⁵,
Hyosoo Shin⁴,⁵,
View ORCID ProfileEun Young Choi⁶,†,
View ORCID ProfileJong-Sup Bae ⁷,† and
View ORCID ProfileWonhwa Lee ⁵,⁷,†

¹Department of Biotechnology and Bioengineering, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea.
²Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
³Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.
⁴College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
⁵Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
⁶Department of Internal Medicine, Yeungnam University Medical Center, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea.
⁷College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.

↵†Corresponding author. Email: letact{at}hanmail.net (E.Y.C.); baejs{at}knu.ac.kr (J.-S.B.); wonhwalee{at}kribb.re.kr (W.L.)

↵* These authors contributed equally to this work.

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Science Advances 31 Jul 2020:
Vol. 6, no. 31, eabc1564
DOI: 10.1126/sciadv.abc1564

Hee Ho Park

1Department of Biotechnology and Bioengineering, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea.

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Hong Nam Kim

2Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

3Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.

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Hyelim Kim

4College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.

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Youngbum Yoo

5Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

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Hyosoo Shin

4College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.

5Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

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Eun Young Choi

6Department of Internal Medicine, Yeungnam University Medical Center, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea.

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For correspondence: letact@hanmail.net baejs@knu.ac.kr wonhwalee@kribb.re.kr

Jong-Sup Bae

7College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.

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For correspondence: letact@hanmail.net baejs@knu.ac.kr wonhwalee@kribb.re.kr

Wonhwa Lee

5Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

7College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.

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ORCID record for Wonhwa Lee
For correspondence: letact@hanmail.net baejs@knu.ac.kr wonhwalee@kribb.re.kr

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Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia

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