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Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

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Science Advances  31 Jul 2020:
Vol. 6, no. 31, eabc5801
DOI: 10.1126/sciadv.abc5801

Article Information

vol. 6 no. 31

Online ISSN: 
  • Received for publication May 1, 2020
  • Accepted for publication June 18, 2020
  • .

Author Information

  1. David H. Brann1,,
  2. Tatsuya Tsukahara1,,
  3. Caleb Weinreb1,,
  4. Marcela Lipovsek2,
  5. Koen Van den Berge3,4,
  6. Boying Gong5,
  7. Rebecca Chance6,
  8. Iain C. Macaulay7,
  9. Hsin-Jung Chou6,
  10. Russell B. Fletcher6,8,
  11. Diya Das6,9,10,
  12. Kelly Street11,12,
  13. Hector Roux de Bezieux5,13,
  14. Yoon-Gi Choi14,
  15. Davide Risso15,
  16. Sandrine Dudoit3,5,
  17. Elizabeth Purdom3,
  18. Jonathan Mill16,
  19. Ralph Abi Hachem17,
  20. Hiroaki Matsunami18,
  21. Darren W. Logan19,
  22. Bradley J. Goldstein17,
  23. Matthew S. Grubb2,
  24. John Ngai6,14,20,21 and
  25. Sandeep Robert Datta1,*
  1. 1Harvard Medical School Department of Neurobiology, Boston MA 02115 USA.
  2. 2Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London SE1 1UL, UK
  3. 3Department of Statistics, University of California, Berkeley, CA 94720
  4. 4Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium
  5. 5Division of Biostatistics, School of Public Health, University of California, Berkeley, CA 94720
  6. 6Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720
  7. 7Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, UK
  8. 8Present address: Surrozen, Inc., South San Francisco, CA 94080
  9. 9Berkeley Institute for Data Science, University of California, Berkeley
  10. 10Present address: Genentech, Inc., South San Francisco, CA 94080
  11. 11Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA
  12. 12Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA
  13. 13Center for Computational Biology, University of California, Berkeley, CA 94720
  14. 14QB3 Functional Genomics Laboratory, University of California, Berkeley, CA 94720
  15. 15Department of Statistical Sciences, University of Padova, Padova, Italy
  16. 16University of Exeter Medical School, College of Medicine & Health, University of Exeter, Exeter EX2 5DW, UK
  17. 17Duke University School of Medicine Department of Head and Neck Surgery & Communication Sciences, Durham, NC 27717 USA.
  18. 18Duke University School of Medicine Department of Molecular Genetics and Microbiology, Department of Neurobiology, Duke Institute for Brain Sciences, Durham, NC 27717 US
  19. 19Waltham Petcare Science Institute, Leicestershire LE14 4RT, UK.
  20. 20Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720
  21. 21Present address: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
  1. *To whom correspondence should be addressed: srdatta{at}
  • These authors contributed equally to this work.


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