Research ArticleVIROLOGY
Development of a potent Zika virus vaccine using self-amplifying messenger RNA
- View ORCID ProfileKate Luisi1,*,
- View ORCID ProfileKaitlyn M. Morabito2,*,
- View ORCID ProfileKatherine E. Burgomaster3,*,
- Mayuri Sharma1,†,
- Wing-Pui Kong2,
- Bryant M. Foreman3,
- Sonal Patel1,
- Brian Fisher2,
- View ORCID ProfileMaya A. Aleshnick3,‡,
- Jason Laliberte1,
- View ORCID ProfileMadison Wallace1,
- View ORCID ProfileTracy J. Ruckwardt2,
- David N. Gordon3,
- Christine Linton1,§,
- Nicole Ruggiero1,||,
- Jessica L. Cohen1,
- Russell Johnson1,
- Kunal Aggarwal1,
- View ORCID ProfileSung-Youl Ko2,
- Eun Sung Yang2,
- View ORCID ProfileRebecca S. Pelc3,¶,
- View ORCID ProfileKimberly A. Dowd3,
- Derek O’Hagan1,
- Jeffrey Ulmer1,
- Sally Mossman1,
- Anna Sambor1,
- Edith Lepine1,#,
- View ORCID ProfileJohn R. Mascola2,
- View ORCID ProfileTheodore C. Pierson3,**,
- View ORCID ProfileBarney S. Graham2,** and
- View ORCID ProfileDong Yu1,**
- 1GSK Vaccines, Rockville, MD 20850, USA.
- 2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- 3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- ↵**Corresponding author. Email: dong.x.yu{at}gsk.com (D.Y.); bgraham{at}mail.nih.gov (B.S.G.); piersontc{at}mail.nih.gov (T.C.P.)
↵* These authors contributed equally to this work.
↵† Present address: Takeda Pharmaceuticals, 35 Lansdowne Street, Cambridge, MA, USA.
↵‡ Present address: Oregon Health and Science University, 15700 SW Greystone Ct, Beaverton, OR 97006, USA.
↵§ Present address: Janssen Pharmaceutical Companies of J&J, Spring House, PA, USA.
↵|| Present address: Matrivax, 650 Albany Street, Boston, MA, USA.
↵¶ Present address: North Carolina State Laboratory of Public Health, Raleigh, NC, USA.
↵# Present address: Vetoquinol, Lavaltrie, Canada.
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Science Advances 07 Aug 2020:
Vol. 6, no. 32, eaba5068
DOI: 10.1126/sciadv.aba5068
Vol. 6, no. 32, eaba5068
DOI: 10.1126/sciadv.aba5068
Kate Luisi
1GSK Vaccines, Rockville, MD 20850, USA.
Kaitlyn M. Morabito
2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Katherine E. Burgomaster
3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Mayuri Sharma
1GSK Vaccines, Rockville, MD 20850, USA.
Wing-Pui Kong
2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Bryant M. Foreman
3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sonal Patel
1GSK Vaccines, Rockville, MD 20850, USA.
Brian Fisher
2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Maya A. Aleshnick
3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Jason Laliberte
1GSK Vaccines, Rockville, MD 20850, USA.
Madison Wallace
1GSK Vaccines, Rockville, MD 20850, USA.
Tracy J. Ruckwardt
2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
David N. Gordon
3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Christine Linton
1GSK Vaccines, Rockville, MD 20850, USA.
Nicole Ruggiero
1GSK Vaccines, Rockville, MD 20850, USA.
Jessica L. Cohen
1GSK Vaccines, Rockville, MD 20850, USA.
Russell Johnson
1GSK Vaccines, Rockville, MD 20850, USA.
Kunal Aggarwal
1GSK Vaccines, Rockville, MD 20850, USA.
Sung-Youl Ko
2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Eun Sung Yang
2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Rebecca S. Pelc
3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kimberly A. Dowd
3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Derek O’Hagan
1GSK Vaccines, Rockville, MD 20850, USA.
Jeffrey Ulmer
1GSK Vaccines, Rockville, MD 20850, USA.
Sally Mossman
1GSK Vaccines, Rockville, MD 20850, USA.
Anna Sambor
1GSK Vaccines, Rockville, MD 20850, USA.
Edith Lepine
1GSK Vaccines, Rockville, MD 20850, USA.
John R. Mascola
2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Theodore C. Pierson
3Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Barney S. Graham
2Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Dong Yu
1GSK Vaccines, Rockville, MD 20850, USA.
